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Mesna drug leafletNo. 171 - CIRCUM-PACIFIC JURASSIC G.E.G. Westermann, Department of Geology, McMaster University, Hamilton, Ontario L8S 4M1, Canada. Description: The project aims at promoting interdisciplinary and intercontinental research on the following 12 topics concerning the Jurassic of the Pacific region: 1 ; Geodynamics. A considerable amount of doping drugs consisted of illegal experimental substances whose side and late effects were not clarified. Since athletes reached the threshold value while still juniors, they had a long career in doping drug abuse in technical-compositional kinds of sport, weight-lifting, and swimming beginning already in childhood ; . Athletic achievement was considered to be of higher value than the athletes' actual or future state of health. After the end of a career the health data were falsified without the victims' knowledge. Summing up the results of this overview there is one important, most simple and most verifiable "lesson N mid-April of this year, Victorian Police Minister, Andre Haermeyer, announced a plan to police relating to securing the community by enlisting groups of volunteers to conduct patrols of residential areas. According to the Minister, the plan would be based in part on a model currently enjoying success in T exas in the United States. According to Minister Haermeyer, the mobile citizens' patrols in Texas has successfully curbed criminal activity such as car thefts, thefts from cars and burglaries. If implemented in Australia, the Minister sees it as being essentially an extension of the already successful Neighbourhood Watch programme, by making it pro-active. What is of interest about this situation is the speed with which the Victorian Police Association condemned the idea. In an article by Ian Munro, published in the Herald-Sun, April 15 2002, only the day after the announcement was made, the Association's Assistant Secretary, Bruce McKenzie, was reported to have said, "the association opposed any form of auxiliary or voluntary policing." Why? I find this comment puzzling in the face of recent statements made by senior police in which they have stated that the best way forward in achieving a safer community is through a partnership approach with local communities. I not against the police. I believe in the police and strongly believe that neither private security nor members of the community should ever attempt to replace police - but that is clearly not what is being suggested. The plan is to utilise a volunteer force of community minded people to assist police in more effectively detecting and deterring criminal activity. Obviously, there would need to be careful consideration given to how this would be done, what kind of training such volunteers might need and how the system would be managed. The report in the Herald-Sun went on to quote Mr McKenzie as saying, "The Minister has been over to the US and brought back this hare-brained scheme but he has not brought. 5. Keohan, M. L., and Taub, R. N. Chemotherapy for advanced sarcoma: therapeutic decisions and modalities. Semin. Oncol., 24: 572 579, Santoro, A., Tursz, T., Mouridsen, H., Verweij, J., Steward, W., Somers, R., Buesa, J., Casali, P., Spooner, D., and Rankin, E. Doxorubicin versus CYVADIC versus doxorubicin plus ifosfamide in first-line treatment of advanced soft tissue sarcomas: a randomized study of the European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group. J. Clin. Oncol., 13: 15371545, 1995. Edmonson, J. H., Ryan, L. M., Blum, R. H., Brooks, J. S., Shiraki, M., Frytak, S., and Parkinson, D. R. Randomized comparison of doxorubicin alone versus ifosfamide plus doxorubicin or mitomycin, doxorubicin, and cisplatin against advanced soft tissue sarcomas. J. Clin. Oncol., 11: 1269 1275, Bramwell, V. H. C., Anderson, D., and Charette, M. L. Doxorubicinbased chemotherapy for the palliative treatment of adult patients with locally advanced or metastatic soft tissue sarcoma. A meta-analysis and clinical practice guideline. Sarcoma, 4: 103112, 2000. Antman, K., Crowley, J., Balcerzak, S. P., Rivkin, S. E., Weiss, G. R., Elias, A., Natale, R. B., Cooper, R. M., Barlogie, B., and Trump, D. L. An intergroup Phase III randomized study of doxorubicin and dacarbazine with or without ifosfamide and mesna in advanced soft tissue and bone sarcomas. J. Clin. Oncol., 11: 1276 1285, Van Glabbeke, M., van Oosterom, A. T., Oosterhuis, J. W., Mouridsen, H., Crowther, D., Somers, R., Verweij, J., Santoro, A., Buesa, J., and Tursz, T. Prognostic factors for the outcome of chemotherapy in advanced soft tissue sarcoma: an analysis of 2, 185 patients treated with anthracycline-containing first-line regimens--a European Organization for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group Study. J. Clin. Oncol., 17: 150 157, Jaques, D. P., Coit, D. G., Caspar, E. S., and Brennan, M. P. Hepatic metastases from soft tissue sarcoma. Ann. Surg., 221: 392397, 1995. Goss, G. A., Merriam, P., Manola, J., Singer, S., Fletcher, C. D., and Demetri, G. D. Clinical and pathological characteristics of gastrointestinal stromal tumors GIST ; . Proc. Am. Soc. Clin. Oncol. Annu. Meet., 19: 559a, 2000. Ling, V. Multidrug resistance: molecular mechanisms and clinical relevance. Cancer Chemother. Pharmacol., 40: S3S8, 1997. 14. Bradshaw, D. M., and Arceci, R. J. Clinical relevance of transmembrane drug efflux as a mechanism of multidrug resistance. J. Clin. Oncol., 16: 3674 3690, Germann, U. A. P-Glycoprotein--a mediator of multidrug resistance in tumour cells. Eur. J. Cancer, 32A: 927944, 1996. Loe, D. W., Deeley, R. G., and Cole, S. P. C. Biology of the multidrug resistance protein, MRP. Eur. J. Cancer, 32A: 945957, 1996. Stein, U., Shoemaker, R. H., and Schlag, P. M. MDR1 gene expression: evaluation of its use as a molecular marker for prognosis and chemotherapy of bone and soft tissue sarcomas. Eur. J. Cancer, 32A: 86 92, Toffoli, G., Frustaci, S., Tumiotto, L., Talamini, R., Gherlinzoni, F., Picci, P., and Boiocchi, M. Expression of MDR1 and GST- in human soft tissue sarcomas: relation to drug resistance and biological aggressiveness. Ann. Oncol., 3: 63 69, Vergier, B., Cany, L., Bonnet, F., Robert, J., de Mascarel, A., and Coindre, J. M. Expression of MDR1 P glycoprotein in human sarcomas. Br. J. Cancer, 68: 12211226, 1993. Oda, Y., Schneider-Stock, R., Rys, J., Gruchala, A., Niezabitowski, A., and Roessner, A. Reverse transcriptase-polymerase chain reaction amplification of MDR1 gene expression in adult soft tissue sarcomas. Diagn. Mol. Pathol., 5: 98 106, Oda, Y., Schneider-Stock, R., Rys, J., Gruchala, A., Niezabitowski, A., and Roessner, A. Expression of multidrug-resistance-associated protein gene in human soft-tissue sarcomas. J. Cancer Res. Clin. Oncol., 122: 161165, 1996. Plaat, B. E. C., van der Graaf, W. T. A., Hollema, H., Mastik, M. F., Luu, H. H., Hoekstra, H. J., de Vries, E. G. E., and Molenaar, W. M. P-gp, MRP1 and LRP expression in relation to treatment response and survival of adult sarcoma patients treated with epirubicin, vindesine and. Mesna sigmaMesna zajednica kacarevo | Cyclophosphamide hemorrhagic cystitis mesnaNext week's Journal will include full details and an entry form for the 2004 Pharmaceutical Care Awards, sponsored by GlaxoSmithKline. The awards recognise excellence in the development of pharmaceutical care services and give the opportunity to present a showcase of best professional practice. Don't miss pjonline and metamucil!Baxter Healthcare Corporation New Providence, NJ ; announced that it is launching an oral formulation of Mesnex mesna ; tablets as a prophylactic agent to reduce the incidence of ifosfamide-induced hemorrhagic cystitis. Currently, patients with cancer undergoing treatment with the chemotherapy agent Ifex ifosfamide, Bristol-Myers Squibb Oncology, Princeton, NJ ; also receive Mesnex injections to help protect their urinary systems from hemorrhagic cystitis as the ifosfamide is eliminated from their bodies. Adequate levels of Mesnex must be maintained in the urinary system during the entire course of ifosfamide elimination. Because Mesnex has a shorter therapeutic halflife when compared to ifosfamide, successful treatment requires repeated doses of Mesnex. IV Mesnex administration involves a 15minute IV infusion at zero, four, and eight hours after starting ifosfamide. With the availability of Baxter's new Mesnex tablets, recently approved by the U.S. Food and Drug Administration, patients receiving ifosfamide will receive their initial dose of Mesnex via IV at the time of ifosfamide administration and follow up with Mesnex tablets two and six hours after the ifosfamide treatment. This has the potential to significantly shorten the amount of time patients need to stay at infusion centers. The average wholesale price of Mesnex is .50 for each 400 mg tablet. The actual cost will vary according to prescribed dose and retail pricing. Bristol-Myers Squibb Oncology will be copromoting Mesnex tablets during the initial launch period. Bristol-Myers Squibb Oncology also markets and distributes Mesnex injection. For complete prescribing information, please see Baxter's Web site at baxter. Contract manufacturing packing & logistics clients oncology anti cancer injectables ; cisplatin injection carboplatin injection doxorubicin injection docetaxel injection epirubicin injection etoposide injection granisetron injection amifostine injection paclitaxel injection oxaliplatin injection bleomycin injection cytarabine injection cyclophosamide injection cytosine arabinoside injection di-sodium pamidronate injection dacarbazine injection dactinomycin injection daunorubicin injection fludarabine injection gemcitabine injection irinotecan injection ifosfamide injection leuprolide injection l-asparaginase injection methotrexate injection mesna injection mitoxantrone injection topotecan injection vincristine injection vinorelbine injection vinblastine injection zolendronic acid pre-filled syringes antibiotics & anti- infectives new molecules fdc ; liquid ampoules vials biological injections cardiovascular injections neurology other injectables hormones eye ear nasal drops oxaliplatin injection category: anticancer each vial contains: - oxaliplatin… and methadone. Mesna and ifosfamide |
Whether the correct nomenclature is Elaeoluma or Gymnoluma is problematical and remains to be resolved by a monographer. Kukachka, B.F. 1980. Wood anatomy of the neotropical Sapotaceae. XV. Sandwithiodoxa. Res. Pap. FPL-359. Madison, WI: U.S. Department of Agriculture, Forest Service, Forest Products Laboratory. 4 p. Sandwithiodoxa is a monotypic genus established by Aubreville and Pellegrin. making the new combination Sandwithiodoxa egregia Sandw. ; Aubr. and Pellegr. The wood is light brown, very hard, and heavy with an average relative density of 1.09. Individual specimens attain a relative density of 1.21. Floristically it is said to have affinities with Sarcaulus and Pseudocladia, but anatomically it differs from these genera in several details. Kukachka, B.F. 1980. Wood anatomy of the neotropical Sapotaceae. XVI. Paralabatia. Res. Pap. FPL-360. Madison, WI: U.S. Department of Agriculture, Forest Service, Forest Products Laboratory. 6 p. Paralabatia is a small genus of five or six species ranging from the Amazon to the West Indies. From the anatomical standpoint the genus as constituted by Aubreville forms a group of closely related species. In marked contrast, the four species cited by Baehni belong to four different anatomical groups. The woods of Paralabatia are somewhat similar to those of Neoxythece but can be readily distinguished by the smaller pores and shorter vessel members characteristic of Paralabatia. Kukachka, B.F. 1980. Wood anatomy of the neotropical Sapotaceae. XVII. Gambeya. Res. Pap. FPL-361. Madison, WI: U.S. Department of Agriculture, Forest Service, Forest Products Laboratory. 6 p. Gambeya is an African genus to which Aubreville added Gambeya excelsa Huber ; Aubr., based on the Amazonian Chrysophyllum excelsum Huber. Whether Gambeya is the appropriate taxon for the American species remains to be resolved. Wood specimens indicate that several species occur in the Americas ranging from Southern Mexico to the Peruvian Amazon. The woods of the neotropical Gambeya are an off-white color unique among the predominant browns and red browns typical of the Sapotaceae. The wood is further distinguished by the radial arrangement of the pores, reticulate parenchyma, lack of silica, and the presence of microcrystals in the wood rays and axial parenchyma. A unique genus of the Sapotaceae. Kukachka, B.F. 1980. Wood anatomy of the neotropical Sapotaceae. XVIII. Gomphiluma. Res. Pap. FPL-362. Madison, WI: U.S. Department of Agriculture, Forest Service, Forest Products Laboratory. 3 p. As now constituted, Gomphiluma consists of two species of small trees limited to the Brazilian Amazon. Formerly submerged in the large genus Pouteria, Gomphiluma was reinstated to generic status by Aubreville in 1961. The pale brown wood of moderate density is quite unlike that of Pouteria and appears more nearly allied with certain species of Micropholis. Kukachka, B.F. 1980. Wood anatomy of the neotropical Sapotaceae. XIX. Chromolucuma. Res. Pap. FPL-363 and methazolamide.
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It has recently been demonstrated that the pathogenesis of the testiculopathy in a high percentage of severe oligozoospermic and azoospermic patients may be related to microdeletions of the Y chromosome long arm Yq ; Reijo et al., 1995, 1996; Kent-First et al., 1996; Vogt et al., 1996; Foresta et al., 1997, 1998; Pryor et al., 1997 ; , and in previous studies we have observed that Yq microdeletions in highly selected idiopathic severe primary testiculopathies, e.g. severe hypospermatogenesis and Sertoli cell-only syndrome, were present in five of 22 subjects 22.7% ; and 10 out of 18 subjects 55.5% ; respectively Foresta et al., 1997, 1998 ; . ICSI allows fertilization and pregnancy in the presence of severe oligozoospermia and azoospermia utilizing few ejaculated, epididymal or testicular spermatozoa. The possible risks of transmitting genetic abnormalities utilizing this technique have been proposed only very recently, since ICSI bypasses all the physiological mechanisms related to fertilization Foresta et al., 1996a, b ; . ICSI utilizing spermatozoa from these Yq deleted patients will transmit this defect to male children, as recently reported by Kent-First et al. 1996 ; . However, it has been noted that it is possible to have a deletion in the Y chromosome and to father children Stuppia et al., 1996; Vogt et al., 1996; Pryor et al., 1997 ; . On the other hand the origin of Yq deletions is still unknown and only speculative hypotheses can be formulated, as excellently reported recently by Edwards and Bishop 1997 ; . Mulhall et al. 1997 ; have recently reported fertilization and pregnancy achieved utilizing ICSI with testicular spermatozoa from azoospermic patients presenting deletions in the DAZ region of Yq suggesting that Yq microdeletions are compatible with the presence of fully competent spermatozoa. The present report is the first showing that spermatozoa from an oligozoospermic subject presenting Yq microdeletions are able to fertilize oocytes in vitro. These findings undoubtedly demonstrate that spermatozoa carrying Yq deletions possess all the characteristics required for regulating capacitation, acrosome reaction and the ability to penetrate the oocyte and fertilize it, as previously showed also in vivo Stuppia et al., 1996; Vogt et al., 1996; Pryor et al., 1997 ; . PCR analysis, as previously reported by our and other, groups Najmabadi et al., 1996; Foresta et al., 1997, 1998 ; , showed the presence of interstitial double deletions, that can be explained by different hypotheses: i ; the PCR observations may reflect separated microdeletions; ii ; some STSs may be from repetitive sequences and PCR products may reflect amplifications from a different site; iii ; a complex rearrangement may be the cause e.g. an inversion in the father who would still be karyotypically normal with a subsequent interstitial deletion ; . Discontinuous selections seem to occur frequently in the Y chromosome Najmabadi et al., 1996; Foresta et al., 1997, 1998; Girardi et al., 1997 ; , probably because it contains a high frequency of repetitive elements in tandem repeats, rendering this chromosome highly unstable Girardi et al., 1997 ; . The Yq deletion found in our patient is located outside both DAZ and RBM genes, suggesting that regions other than these loci may be associated with spermatogenic impairment, according to recent studies Stuppia et al and methenamine.
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