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BARR, P.-O., BJURSTEDT, H. and COLERIDGE, J. C. G. Changes in the 02 saturation and the pH of the arterial blood in the anaesthetized dog during prolonged . positive acceleration BELCHER, E. H. and HARRISS, EILEEN B. Random destruction of circulating red.

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Demographics: The number of newly diagnosed cases of ADHD in the calendar years 1997 and 1998 was 683, which constituted an incidence of 4.18% of HMO BCBSGA members aged 21 years or less. The 683 case studies were age and sex-matched with a control group. Males comprised 75.4% of new cases, females 24.6%. The incidence of ADHD by age was: reschool kindergarten age children age 0-5 ; 8.6% of cases, elementary school age 6-10 ; totaled 48.5%, junior high school age 11-14 ; 27.7%, and senior high school age 15-21 ; 15.2%. Almost 89% of patients resided in urban areas, while the rest resided in rural areas see table 2 ; . Presentation and Diagnosis: Tests billed in conjunction with a diagnosis of ADHD revealed rare use of test of variable attention TOVA ; 3.2% ; , EEG 2.4% ; , CT 1.6% ; , and MRI 1.5% ; Co-morbidities: According to BCBSGA data, numerous conditions were found to be co-morbid with ADHD in patients as well as their families vs. age and sex-matched controls and their families. Anxiety mood disorder was 10.5 times as likely in patients, and 8.2 times as likely in ADHD families vs. controls. Learning disorders were 9.5 times more frequent in subjects. Other disorders significantly more likely in patients included adjustment disorder, depression, and oppositional defiant disorder ODD ; p 0.05 ; . Disorders more likely in families included ODD, depression, adjustment disorder, and ADHD p 0.05 ; see figure 1 ; . Treatment: According to BCBSGA data, drug therapy was the mainstay of treatment, with 84.4% of cases receiving some kind of pharmacotherapy. Counseling was sought by 43.6% of patients, with an average length of treatment of 1.93 months. Ritalin methylphenydate ; was the drug of choice, with 35.6% of all prescriptions, followed by Adderall at 26.6%, Dexedrine 8.6%, Wellbutrin 4.1%, and Cylert 3.2%, Tegretol 1.5%, Catapres 1.5%, Mellaril 1.3%, Tofranil 1.0%, Lithium 0.9%, and Norpramine 0.9%. see figure 2 ; . A neurologist referral was made in 12.9% of cases, and 2 cases required hospitalization under the primary diagnosis of ADHD. In terms of cost, Ritalin comprised 48% of total drug cost, while Adderall comprised only 25% of cost, and Dexedrine 10%. Total cost of drug therapy was 2, 671, and total cost of counseling therapy was , 576. Neurologists claimed , 337. Discussion Overall, the results of the study correlate closely with the American Academy of Pediatrics national literature review and consultation with numerous pediatric specialists 5 ; . The 3-1 male to female preponderance also coincides with national averages, which estimate a 9.2% male and a 2.9% female prevalence. This is thought to be because males are usually more active and aggressive, and therefore come to the attention of teachers and parents more.

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Through 5 ; ICE ; . Consolidation therapy included mitoxantrone 8 mg m2 d on days 4 through 6 ; and Ara-C 2 x 500 mg m21d on days 1 through 6 ; NOVIA ; . UPN 5 was refractory to the initial RI course and received a second intensified RI and consolidation course consisting of high-dose Ara-C 2 X 3 g days 1 through 6 ; . Because of poor autologous marrow harvests in UPN 2, 3, and 4 ; and lack of allogeneic donors, all patients underwent autologous PBPC collection in complete hematologic remission at a mean interval of 135 days range, 63 to 237 days ; after diagnosis. Patients were harvested after mobilization with growth factors alone Granulocyte colony-stimulating factor [G-CSF], Amgen, Thousand Oaks, CA, and RhBne Poulenc, Paris, France ; or the combination of chemotherapy h a - C and NOVIA ; followed by growth factors. All patients had a normal karyotype at time of PBPC harvesting. The most commonly prescribed stimulant in America is Ritalin Methylphenidate ; . Others include Dexedrine, Adderall, and Cylert Pemoline ; . All are in the amphetamine family and are related to "speed". It seems paradoxical that "speed" should help a "hyperactive" child. However, the common "image" of what speed does is based on very high doses taken by drug abusing adults. These medications behave differently in low doses and in children. At a very low dose, stimulants improve attention in all age groups ; . As an example of how that works, think about caffeine. Caffeine acts in a very similar way to the amphetamine-like.

Some degree of insulin resistance may occur in one-half of people taking PIs. Research also indicates that coinfection with the hepatitis C virus HCV ; --which affects as many as 40% of people with HIV in the U.S.-- increases the risk of blood glucose abnormalities. Studies have shown that people with chronic hepatitis C are more likely to develop insulin resistance and type 2 diabetes. For example, Shruti Mehta, MPH, and colleagues from Johns Hopkins University in Baltimore found that people with HCV were four times more likely to develop type 2 diabetes than HCV negative people; however, they found no association between hepatitis B and diabetes. Mehta's team also found that HIV HCV-coinfected people were five times more likely to develop hyperglycemia than those with HIV alone. Similarly, Michel Duong, MD, and colleagues from Dijon studied 29 HIV HCV-coinfected individuals receiving HAART, 76 people with HIV alone, and 121 with HCV alone. Both the coinfected subjects and those with HCV alone had a significantly higher rate of insulin resistance than those with only HIV. Although it is not clear how chronic hepatitis promotes blood sugar abnormalities, it is believed that liver damage affects the metabolism of glycogen and the production of glucose. In a letter published in the December 15, 2003 issue of the Journal of Acquired Immune Deficiency Syndromes JAIDS ; , Raymond Chung, MD, and colleagues from Harvard Medical School and Massachusetts General Hospital in Boston reported that elevated alanine transaminase ALT ; liver enzyme levels--an indication of liver inflammation--predicted insulin resistance in HIV positive individuals with lipodystrophy whether or not they were coinfected with hepatitis B or C. not yet known whether blood glucose abnormalities in people with HIV will have the same negative health consequences as they do in the population at large, though there is little reason to expect otherwise and cytarabine.

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Recipients still experience acute rejection episodes that may require aggressive treatment and or hospitalization to prevent loss of the organ. Clinical trials showed that Simulect, used with another drug, reduced the incidence of acute rejection by nearly one-third during the first six months following a transplant. Thymoglobulin anti-thymocyte globulin, [rabbit] ; is to prevent the loss of a transplanted kidney by patients experiencing acute rejection of the organ. A polyclonal antibody, Thymoglobulin reversed acute-organ rejection in 78 percent of kidney-transplant patients in a pivotal Phase III clinical trial of 163 patients. Eighty-three percent of the patients treated with the biologic retained their transplanted kidneys one year later and 93 percent of the patients were still alive. Approval of Thymoglobulin was obtained by SangStat, The Transplant Company Although it is usually thought of as a male hormone, women's bodies also make testosterone, but at much lower levels than men's. Testosterone has two different effects on the body: anabolic effects which promote growth and muscle building, and androgenic effects which develop the male sex organs and secondary sex characteristics such as deepening of the voice and growth of facial hair and cytomel. Rostacyclin, a metabolite of arachidonic acid, has vasoprotective effects, including vasodilation, antiplatelet aggregation, and inhibition of smooth muscle cell proliferation.1, 2 Prostacyclin synthase PGIS ; catalyzes the conversion of prostaglandin H2 to prostacyclin. In 1994, we determined the amino acid sequence of human endothelial PGIS by cDNA cloning.3 Recently, we showed that introduction of the PGIS cDNA into rat carotid artery after balloon-induced injury results in increased prostacyclin synthesis and inhibition of smooth muscle cell proliferation.4 These results raise the possibility that in vivo gene transfer of PGIS could have beneficial effects in patients with vascular disease. Primary pulmonary hypertension PPH ; is a rare but life-threatening disease characterized by progressive pulmonary hypertension, ultimately producing right ventricular RV ; failure and death.5 Interestingly, PGIS deficiency in the lungs and impaired prostacyclin production have been linked to the development of pulmonary hypertension in this dis.
Number of Number of securities securities to be remaining available for issued upon future issuance under exercise of Weighted-average equity compensation outstanding exercise price of plans excluding options, warrants outstanding options, securities reflected in and rights warrants and rights column a Plan Category a ; b ; c ; compensation plans approved by security holders 3, 663, 600 .11 1, 235, 000 compensation plans not approved by security holders None N A 348, 552 3, .11 1, 583, 552 and cytoxan.

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Psychiatry Dept. of Psychiatry, University of Illinois at Chicago is seeking non-tenure Assistant Professor with a background in both public health and nursing to administratively direct the departmental Quality Management Program and serve as the clinical director of the First Episode Psychosis Program. This position involves a 50% departmental QA administrative appointments and 50- administrative clinical research appointment within the Psychosis Program. Responsibilities include developing and maintaining QA initiatives for the department while also serving as the liaison to state organizations. Additionally, responsibilities in the First Episode Psychosis Program include administrative oversight, program development, and research. Applicants should have Ph.D. degree. C.85. Airoldi, F; Di Mario, C; Ribichini, F; Presbitero, P; Sganzerla, P; Ferrero, V; Vassanelli, C; Briguori, C; Carlino, M; Montorfano, M; Biondi-Zoccai, GGL; Chieffo, A; Feffari, A; Colombo, A. 17-beta-estradiol eluting stent versus phosphorylcholine-coated Stent for the treatment of native coronary artery disease. Am. J. Cardiol.: 2005; 96 5 ; : 664-667 - Article C.86. Alfieri, O; Maisano, F; Colombo, A. Future of transcatheter repair of the mitral valve. Am. J. Cardiol. : 2005; 96 12A ; : 71L75L - Article C.87. Aoki, J; Colombo, A; Dudek, D; Banning, AP; Drzewiecki, J; Zmudka, K; Schiele, F; Russell, ME; Koglin, J; Serruys, PW. Peristent remodeling and neointimal suppression 2 years after polymer-based, paclitaxel-eluting stent implantation insights from serial intravascular ultrasound analysis in the TAXUS II study. Circulation: 2005; 112 25 ; : 3876-3883 - Article C.88. Baldi, S; Ruffini, E; Harari, S; Roviaro, GC; Nosotti, M; Bellaviti, N; Venuta, F; Diso, D; Rea, F; Schiraldi, C; Durigato, A; Pavanello, M; Carretta, A; Zannini, P. Does lobectomy for lung cancer in patients with chronic obstructive pulmonary disease affect lung function? A multicenter national study. J. Thorac. Cardiovasc. Surg.: 2005; 130 6 ; : 1616-1622 - Article C.89. Benussi, S; Nascimbene, S; Calori, G; Denti, P; Ziskind, Z; Kassem, S; La Canna, G; Pappone, C; Alfieri, O. Surgical ablation of atrial fibrillation with a novel bipolar radiofrequency device. J. Thorac. Cardiovasc. Surg.: 2005; 130 2 ; : 491 - 497 - Article C.90. Biondi-Zoccai GG, Sangiorgi GM, Chieffo A, Vittori G, Falchetti E, Margheri M, Barbagallo R, Tamburino C, Remigi E, Briguori C, Iakovou I, Agostoni P, Tsagalou E, Melzi G, Michev I, Airoldi F, Montorfano M, Carlino M, Colombo A; RECIPE Real-world Eluting-stent Comparative Italian retrosPective Evaluation ; Study Investigators. Validation of predictors of intraprocedural stent thrombosis in the drug-eluting stent era. Am. J. Cardiol.: 2005; 95 12 ; : 1466-1468 - Article C.91. Biondi-Zoccai, GG; Agostoni, P; Sangiorgi, GM; Airoldi, F; Cosgrave, J; Chieffo, A; Barbagallo, R; Tamburino, C; Vittori, G; Falchetti, E; Margheri, M; Briguori, C; Remigi, E; Iakovou, I; Colombo, A. Incidence, predictors, and outcomes of coronary dissections left untreated after drug-eluting stent implantation. Eur. Heart J.: 2005; Nov 11 [Epub ahead of print] C.92. Biondi-Zoccai, GGL; Agostoni, P; Abbate, A; Airoldi, F; Colombo, A. Critical role of bare-metal stent controls in trials of drug-eluting stents. Eur. Heart J.: 2005; 26 16 ; : 1686 - 1687 Letter C.93. Biondi-Zoccai, GGL; Agostoni, P; Abbate, A; Testa, L; Burzotta, F. A simple hint to improve Robinson and Dickersin's highly sensitive PubMed search strategy for controlled clinical trials. Int. J. Epidemiol.: 2005; 34 1 ; : 224-225 - Letter C.94. Biondi-Zoccai, GL; Agostoni, P; Abbate, A; Testa, L; Burzotta, F; Lotrionte, M; Crea, F; Biasucci, LM; Vetrovec, GW; Colombo, A. Adjusted indirect comparison of intracoronary drug-eluting stents: evidence from a metaanalysis of randomized bare-metal-stent-controlled trials. Int. J. Cardiol.: 2005; 100 1 ; : 119-123 - Article C.95. Bove, T; Landoni, G; Calabro, MG; Aletti, G; Marino, G; Cerchierini, E; Crescenzi, G; Zangrillo, A. Renoprotective action of fenoldopam in high-risk patients undergoing cardiac surgery A prospective, double-blind, randomized clinical trial. Circulation: 2005; 111 24 ; : 3230-3235 - Article C.96. Briguori, C; Colombo, A. Statins and percutaneous coronary intervention: reply. Eur. Heart J.: 2005; 26 4 ; : 417-418 - Letter C.97. Briguori, C; Colombo, A; Airoldi, F; Focaccio, A; Iakovou, L; Chieffo, A; Michev, I; Montorfano, M; Bonizzoni, E; Ricciardelli, B; Condorelli, G. Sirolimus-eluting stent implantation in diabetic patients with multivessel coronary artery disease. Am. Heart J.: 2005; 150 4 ; : 807-813 - Article C.98. Briguori, C; Colombo, A; Airoldi, F; Morici, N; Sangiorgi, GM; Violante, A; Focaccio, A; Montorfano, M; Carlino, M; Condorelli, G; Ricciardelli, B. Nephrotoxicity of low-osmolality versus iso-osmolality contrast agents: Impact of N-acetylcysteine. Kidney Int.: 2005; 68 5 ; : 2250-2255 C.99. Briguori, C; Condorelli, G; Airoldi, F; Manganelli, F; Violante, A; Focaccio, A; Ricciardelli, B; Colombo, A. Impact of microvascular complications on outcome after coronary stent implantations in patients with diabetes. J.Am.Coll rdiol.: 2005; 45 3 ; : 464-466 C.100. Calabresi, L; Pisciotta, L; Costantin, A; Frigerio, I; Eberini, I; Alessandrini, P; Arca, M; Bon, GB; Boscutti, G; Busnach, G; Frasca, G; Gesualdo, L; Gigante, M; Lupattelli, G; Montali, A; Pizzolitto, S; Rabbone, I; Rolleri, M; Ruotolo, G; Sampietro, T; Sessa, A; Vaudo, G; Cantafora, A; Veglia, F; Calandra, S; Bertolini, S; Franceschini, G. The molecular basis of lecithin : cholesterol acyltransferase deficiency syndromes - A comprehensive study of molecular and biochemical findings in 13 unrelated Italian families. Arterioscler. Thromb. Vasc. Biol.: 2005; 25 9 ; : 1972-1978 - Article C.101. Chieffo, A; Stankovic, G; Bonizzoni, E; Tsagalou, E; Iakovou, I; Montorfano, M; Airoldi, F; Michev, I; Sangiorgi, MG; Carlino, M; Vitrella, G; Colombo, A. Early and mid-term results of drug-eluting dtent implantation in unprotected left main. Circulation: 2005; 111 6 ; : 791-795 - Article C.102. Chiesa, R; Astore, D; Guzzo, G; Frigerio, S; Tshomba, Y; Castellano, R; de Moura, MRL; Melissano, G. Visceral artery aneurysms. Ann. Vasc. Surg.: 2005; 19 1 ; : 42-48 - Article C.103. Chiesa, R; Marone, EM; Limoni, C; Volonte, M; Schaefer, E; Petrini, O. Chronic venous insufficiency in Italy: the 24-cities cohort study. Eur. J. Vasc. Endovasc. Surg.: 2005; 30 4 ; : 422-429 - Article C.104. Chiesa, R; Marone, EM; Limoni, C; Volonte, M; Schaefer, E; Petrini, O. Demographic factors and their relationship with the presence of CVI signs in Italy: the 24-cities cohort study. Eur. J. Vasc. Endovasc. Surg.: 2005; 30 6 ; : 674-680 - Article C.105. Chiesa, R; Melissano, G; Marrocco-Trischitta, MM; Civilini, E; Setacci, F. Spinal cord ischemia after elective stent-graft repair of the thoracic aorta. J. Vasc. Surg.: 2005; 42 1 ; : 11-17 - Article C.106. Chimenti, C; Pieroni, A; Russo, A; Sale, P; Russo, MA; Maseri, A; Frustaci, A. Laser microdissection in clinical cardiovascular research. Chest: 2005; 128 4 ; : 2876-2881 - Review C.107. Chimenti, C; Pieroni, M; Frustaci, A. Letter regarding article by Abbate et al, "Widespread myocardial inflammation and infarct-related artery patency". Circulation: 2005; 111 2 ; : E17E17 - Letter C.108. Ciriaco, P; Casiraghi, M; Melloni, G; Carretta, A; Libretti, L; Augello, G; Zannini, P. Pulmonary resection for non-smallcell lung cancer in patients on hemodialysis: Clinical outcome and long-term results. World J.Surg.: 2005; 29 11 ; : 1516-1519 - Article C.109. Colombo, A. Another attempt to deal with restenosis. Catheter. Cardiovasc. Interv.: 2005; 64 4 ; : 419-420 - Editorial Material C.110. Colombo, A. Bifurcational lesions: Searching the solution. Catheter. Cardiovasc. Interv.: 2005; 65 1 ; : 17-18 - Editorial Material C.111. Colombo, A; Cosgrave, J. Paclitaxel-eluting stents in complex lesions. JAMA-J. Am. Med. Assoc.: 2005; 294 10 ; : 12681270 - Editorial Material C.112. Colombo, A; Mikhail, GW; Michev, I; Iakovou, I; Airoldi, F; Chieffo, A; Rogacka, R; Carlino, M; Montorfano, M; Sangiorgi, GM; Corvaja, N; Stankovic, G. Treating chronic total occlusions using subintimal tracking and reentry: The STAR tech and dacarbazine.

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Violence and murder.57, 58 Ellingwood59 reported a series of cases in which amphetamines were related to homicide, detailing the amphetamine-induced alterations in behavior and thought that led to homicide. These included reduced impulse control, paranoia, panic, and emotional instability N 13 ; . summarize, the psychiatric side effects of methylphenidate are quite similar to those of cocaine and amphetamines, giving more support to the idea that almost all CNS stimulants will produce a similar clinical picture. A person using cocaine can experience nervousness, 57, 58 restlessness, 58 agitation, 57 suspiciousness, 60 paranoia, 6163 hallucinations and delusions, 61, 63 impaired cognitive functions, 64 delirium, 65 violence, 57, 58, 62, suicide, 67 and homicide.6770 CONCLUSION.

That tribes have been found in other parts of America, distinguished from the neighbouring tribes by the less tawny colour of their skin. Such are the Arivirianos and Maquiritares of the Rio Ventuario and the Padamo, the Paudacotos and Paravenas of the Erevato, the Viras and Araguas of the Caura, the Mologagos of Brazil, and the Guayanas of the Uruguay. * * The Cumanagotos, the Maypures, the Mapojos, and some hordes of the Tamanacs, are also fair, but in a less degree than the tribes I have just named. We may add to this list which the researches of Sommering, Blumenbach, and Pritchard, on the varieties of the human species, have rendered so interesting ; the Ojes of the Cuchivero, the Boanes now almost destroyed ; of the interior of Brazil, and in the north of America, far from the north-west coast, the Mandans and the Akanas Walkenaer, Geogr. page 645. Gili volume 2 page 34. Vater, Amerikan. Sprachen page 81. Southey volume 1 page 603. ; The most tawny, we might almost say the blackest of the American race, are the Otomacs and the Guamos. These have perhaps given rise to the confused notions of and daclizumab. Panel A, there are impaired conduction and excitability in a segment of the reentrant circuit delineated by the two lines ; . Further depression of conduction and excitability will result in conduction block in that segment. As a precondition in panel B, conduction during the reentrant tachycardia encroaches on the relative refractory period. Prolongation of refractoriness will cause block of the reentrant wavefront in its own refractory tail or the impulse may merely slow down ; . In panel C, fibrillation is maintained by the presence of many independent wavefronts. Prolongation of the wavelength ofrefractoriness reduces the number of wavefronts in a given chamber below a critical number; block and collision terminate the arrhythmia.

Which processes in a hill-climbing manner. The parameters are modified in the direction specified by the gradient of the MMI objective function, whereas the magnitude of an update is a constant , known as the learning rate, times the magnitude of this gradient. Although the GD algorithm is a general technique that is guaranteed to locate the local maximum, its main disadvantage is the slow speed of convergence, which may take up to infinite iterations, especially when applied to the complex MMI objective function and dactinomycin.

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The goals of treatment of chronic hepatitis B are 3-fold: i ; to slow the progression of fibrosis to cirrhosis; ii ; to prevent hepatic failure; and iii ; to prevent the development of hepatocellular carcinoma HCC ; . There is no cure for hepatitis B. HBV is maintained in a replicative form in the hepatocyte nuclei termed covalently closed circular DNA cccDNA ; which serves as a template for viral transcription. Current therapies have little or no direct effect on cccDNA. Hence, viral relapse occurs once antiviral medications are discontinued. Because HBV cannot be eradicated, the efficacy of antiviral therapy of chronic hepatitis B is measured using surrogate markers. These include suppression of HBV DNA, normalization of alanine aminotransferase ALT ; , and loss of hepatitis B e antigen HBeAg ; or hepatitis B surface antigen HBsAg ; . The course of chronic HBV infection is characterized by periods of activity and quiescence. Thus, all HBV carriers should be regularly monitored and dalteparin.

People with hiv are more susceptible to STDs Sexually Transmitted Diseases ; . Once you have an STD, you can transmit hiv to someone else more easily. You can read all.

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Logic dictates that diabetes treatments and guidelines should be the same in both Canada and the U.S., if not worldwide. After all, don't clinicians and diabetes associations draw on the same research to formulate their recommendations? It's not that simple. "Different countries have a different incidence of diabetes, different healthcare systems and different reimbursement structures, " says Dr. Hertzel Gerstein, director of the division of endocrinology and metabolism at McMaster University in Hamilton. "Some guidelines follow a `This is what the experts say' approach while others rely more strongly on scientific evidence." The Canadian Diabetes Association's 2003 Clinical Practice Guidelines for the Prevention and Management of Diabetes are evidence-based. "They're the first of their kind and cytarabine.

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Background--The safety and efficacy of sirolimus-eluting stenting have been demonstrated, but the outcome of patients treated with this novel technology beyond the first year remains unknown. We sought to evaluate the angiographic, intravascular ultrasound IVUS ; , and clinical outcomes of patients treated with sirolimus-eluting stents 2 years after implantation. Methods and Results--This study included 30 patients treated with sirolimus-eluting Bx Velocity stenting slow release [SR], n 15, and fast release [FR], n 15 ; in So Paulo, Brazil. Twenty-eight patients underwent 2-year angiographic and IVUS follow-up. No deaths occurred during the study period. In-stent late loss was slightly greater in the FR group 0.28 0.4 mm ; than in the SR group 0.09 0.23 mm, P 0.007 ; . No patient had in-stent restenosis. At 2-year follow-up, only 1 patient FR group ; had a 52% diameter stenosis within the lesion segment, which required repeat revascularization. The target-vessel revascularization rate for the entire cohort was 10% 3 30 ; at 2 years. All other patients had 35% diameter stenosis. Angiographic lumen loss at the stent edges was also minimal in-lesion late loss was 0.33 0.42 mm [FR] and 0.13 0.29 mm [SR] ; . In-stent neointimal hyperplasia volume, as detected by IVUS, remained minimal after 2 years FR 9.90 9 mm3 and SR 10.35 9.3 mm3 ; . Conclusions--This study demonstrates the safety and efficacy of sirolimus-eluting Bx Velocity stents 2 years after implantation in humans. In-stent lumen dimensions remained essentially unchanged at 2-year follow-up in the 2 groups, although angiographic lumen loss was slightly higher in the FR group. Restenosis "catch-up" was not found in our patient population. Circulation. 2003; 107: 381-383. ; Key Words: stents angiography ultrasonics restenosis and danaparoid. There has been 3 plague pandemic recorded in history so far. The latest began in China in 1855, spread to all inhabited continents, and ultimately killed more than 12 milion people in India and China alone. Advances in living conditions, public health, and antibiotic therapy make future pandemics unlikely. However, plague outbreaks following use of a biological weapon are a possible threat
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