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After an exogenous challenge of gonadotropin-releasing hormone in children undergoing pubertal development. J Clin Endocrinol Metab. 79: 814-819. Wide L, Albertsson-Wikland K. 1990 Change in electrophoretic mobility of human follicle-stimulating hormone in serum after administration of gonadotropin-releasing hormone. J Clin Endocrinol Metab. 70~271-276. Blum WFP, Gupta D. 1985 Heterogeneity of rat FSH by chromatofocusing: studies on serum FSH, hormone released in vitro and metabolic clearance rates of its various forms. J Endocrinol. 105: 29-37. Wide L. 1986 The regulation of metabolic clearance rate of human FSH in mice bv variation of the molecular structure of the hormone. Acta Endocrinol Sopenh ; . 1121336-344. Ulloa-Aguirre A, Cravioto A, Dam&-Matsumara P, Jimenez M, Zambrano E, Diaz-Sbnchez V. 1992 Biological characterization of the naturally occurring analogues of intrapituitary human follicle-stimulating hormone. H&n Reprod. 723-30. Filicori M. 1994 Gonadotrophin-releasing hormone agonists. A guide to use and selection. Drugs. 48: 41-58. Crowley WF, Comite F, Vale W, Rivier J, Loriaux DL, Cutler G. 1981 Therapeutic use of pituitary desensitization with long-acting LHRH agonist: a potential new treatment for idiopathic precocious puberty. J Clin Endocrinol Metab. 52: 370-372. Heinrichs C, Craen M, Vanderschueren-Lodeweyckx M, Malvaux P, Fawe L, Bourguignon JP. 1994 Variations in pituitary-gonadal suppression during intranasal buserelin and intramuscular depot-triptorelin therapy for central precocious puberty. Acta Pediatr. 83: 627-633. Matikainen T, Ding Y-Q, Vergara M, Huhtaniemi I, Co&net B, Schaison G. 1992 Differing responses of plasma bioactive and immunoreactive follicle. Introduction Dacarbazine [5- 3, 3-dimethyl-l-triazeno ; imidazole-4-carboxamide] is an alkylating cytostatic drug used in the treatment of various types of human cancer, including malignant melanoma, Hodgkin's lymphoma, soft tissue sarcoma, osteogenic sarcoma and neuroblastoma. High dose dacarbazine up to 1 m2, usually administered as a single agent ; is the chemotherapy of choice in malignant melanoma, with a response rate of ~15-20% 1, 2 ; . In the case of Hodgkin's lymphoma chemotherapy with dacarbazine usually at single doses of 150-200 mg m2 per treatment cycle in combination with other drugs, e.g. adriamycin, bleomycin and vincristine as in the widely used ABVD protocol ; is sometimes preferred instead of the more commonly used procarbazine-based MOPP protocol, because of its lower reproductive toxicity 3 ; . Although dacarbazine-based chemotherapy also appears to be less leukaemogenic than MOPP 4 ; , it is not completely devoid of risk of induction of leukaemogenic activity mainly acute myeloid leukemia ; in long-term survivors and a weak correlation of such activity with the dose of dacarbazine received has been reported 5 ; . However, the currently available evidence does not permit the confident assessment of the contribution if any ; of dacarbazine to the carcinogenic activity of such mixed chemotherapy protocols. Dacarbazine is cytotoxic and mutagenic in various in vitro assays 6-8 ; , while chronic bioassay studies have shown that it has considerable carcinogenic potency in laboratory animals 9-11 ; . For example, following oral or i.p. administration to rats dacarbazine produced tumors of the breast, thymus, spleen, brain and mammary gland 9 ; , while in mice it produced tumors of the lung, hematopoietic tissues and uterus 10, 11 ; . Dacarbazine is converted through a series of changes initiated by liver enzymatic a-hydroxylation of one of its methyl groups into a methylating agent probably the methyldiazonium ion ; , which methylates DNA to produce, among other lesions, the biologically important adduct C -methylguanine C -meG * ; 12 ; . The formation of this adduct in the DNA of experimental animals treated with dacarbazine has been known for a long time 13, 14 ; , while its formation in blood leukocyte DNA of patients with Hodgkin's disease or malignant melanoma treated with dacarbazine has been demonstrated recently 15-17 ; . C -Methylguanine plays an important role in mutagenesis, carcinogenesis and cytotoxicity induced by methylating agents. It is a directly miscoding lesion whose presence in DNA during cell replication directs incorporation of thymine, thus resulting in the generation of G: C-- A: T transition mutations 18-20 ; . Evidence for an in vivo role of C -meG in the genotoxicity of methylating agents has recently come from studies in transgenic mice containing the lacZ or lacl genes as targets for mutagenesis, which have shown that methylating.

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1. Hepatitis B vaccine Hep B ; . All infants should receive the first dose of hepatitis B vaccine soon after birth and before hospital discharge; the first dose may also be given by age 2 months if the infant's mother is HBsAg-negative. Only monovalent hepatitis B vaccine can be used for the birth dose. Monovalent or combination vaccine containing Hep B may be used to complete the series; four doses of vaccine may be administered if combination vaccine is used. The second dose should be given at least 4 weeks after the first dose, except for Hib-containing vaccine which cannot be administered before age 6 weeks. The third dose should be given at least 16 weeks after the first dose and at least 8 weeks after the second dose. The last dose in the vaccination series third or fourth dose ; should not be administered before age 6 months. Infants born to HBsAg-positive mothers should receive hepatitis B vaccine and 0.5 mL hepatitis B immune globulin HBIG ; within 12 hours of birth at separate sites. The second dose is recommended at age 12 months and the vaccination series should be completed third or fourth dose ; at age 6 months. Infants born to mothers whose HBsAg status is unknown should receive the first dose of the hepatitis B vaccine series within 12 hours of birth. Maternal blood should be drawn at the time of delivery to determine the mother's HBsAg status; if the HBsAg test is positive, the infant should receive HBIG as soon as possible no later than age 1 week ; . 2. Diphtheria and tetanus toxoids and acellular pertussis vaccine DTaP ; . The fourth dose of DTaP may be administered as early as age 12 months, provided 6 months have elapsed since the third dose and the child is unlikely to return at age 1518 months. Tetanus and diphtheria toxoids Td ; is recommended at age 1112 years if at least 5 years have elapsed since the last dose of tetanus and diphtheria toxoid-containing vaccine. Subsequent routine Td boosters are recommended every 10 years. 3. Haemophilus influenzae type b Hib ; conjugate vaccine. Three Hib conjugate vaccines are licensed for infant use. If PRP-OMP PedvaxHIB or ComVax [Merck] ; is administered at ages 2 and 4 months, a dose at age 6 months is not required. DTaP Hib combination products should not be used for primary immunization in infants at ages 2, 4, or 6 months, but can be used as boosters following any Hib vaccine. 4. Inactivated polio vaccine IPV ; . An all-IPV schedule is recommended for routine childhood polio vaccination in the United States. All children should receive four doses of IPV at ages 2 months, 4 months, 618 months, and 46 years. 5. Measles, mumps, and rubella vaccine MMR ; . The second dose of MMR is recommended routinely at age 46 years but may be administered during any visit, provided at least 4 weeks have elapsed since the first dose and that both doses are administered beginning at or after age 12 months. Those who have not previously received the second dose should complete the schedule by the 1112 year old visit. 6. Varicella vaccine. Varicella vaccine is recommended at any visit at or after age 12 months for susceptible children, i.e., those who lack a reliable history of chickenpox. Susceptible persons aged 13 years should receive two doses, given at least 4 weeks apart. 7. Pneumococcal vaccine. The heptavalent pneumococcal conjugate vaccine PCV ; is recommended for all children age 223 months. It is also recommended for certain children age 2459 months. Pneumococcal polysaccharide vaccine PPV ; is recommended in addition to PCV for certain high-risk groups. See MMWR 2000; 49 RR-9 135. 8. Hepatitis A vaccine. Hepatitis A vaccine is recommended for use in selected states and regions, and for certain high-risk groups; consult your local public health authority. See MMWR 1999; 48 RR-12 137. 9. Influenza vaccine. Influenza vaccine is recommended annually for children age 6 months with certain risk factors including but not limited to asthma, cardiac disease, sickle cell disease, HIV, diabetes; see MMWR 2001; 50 RR-4 144 ; , and can be administered to all others wishing to obtain immunity. Children aged 12 years should receive vaccine in a dosage appropriate for their age 0.25 mL if age 635 months or 0.5 mL if aged 3 years ; . Children aged 8 years who are receiving influenza vaccine for the first time should receive two doses separated by at least 4 weeks.

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Theory of nonlinear waveguiding due to excitonbiexciton conversion in the nanosemiconductors P.I. KHADZHI, O.V. KOROVAI Dniester State University, Moldova Phone: + 1037333 ; 37023, Fax: + 1037333 ; 34487, email: tdsu4 tirastel.md Theory of nonlinear planar threelayer waveguide, consisting of a linear plate, imbedded into two nonlinear nonKerr semiinfinite media. The dispersion and nonlinearity of which are due to the processes of exciton photon interaction and optical excitonbiexciton conversion is presented. We assume that TEpolarized electromagnetic wave stationary propagates along the waveguide. The theoretical investigation was carried out semiclassically using the material equations for the amplitudes of exciton and biexciton waves and the system of Maxwell equations for the field. From the material equations we obtained the expression for the dielectric function of the crystal. We have found the exact analytical solutions of equations and obtained the expressions for the spatial profiles of the surface and guided modes and the transmitted power. It was shown, that for the same type of mode profile in the plate two types of profile exist in nonlinear medium, namely monotonous and nonmonotonous ones. These modes exist in different ranges of spectrum and transmit different powers. The monotonous modes have the linear solutions as their counterpart, while the nonmonotonous modes have no the linear counterparts at all. If the level of excitation increases, every mode changes its profile and dispersion low. This can lead mode to push out of the guide or to pull it in the guide. Effective refractive index of nonmonotonous profiles has the particular dependence on the power and it is excited at the powers, which exceed the critical one.
27. Support Vector Pursuit Learning, Yanggiiang Liu, Qinming He, Yongchuan Tang . 5841 28. Fuzzy Temporal Sequence Processing by A Fuzzified TSK-type Recurrent Fuzzy. Than 100 original articles and chapters. Other areas of expertise include Lyme disease, headache, and behavioral neurology. Hugos is an instructor in the Department of Neurology at Oregon Health and Science University. She has extensive experience with complex issues surrounding people with multiple sclerosis. She developed the curriculum and participated in the "Fatigue and MS" video-based series on fatigue management, sponsored and produced by the National Multiple Sclerosis Society. She is active in developing Clinical Practice Guidelines for the American Physical Therapy Association, MS Council sponsored by American Academy of Neurology, Consortium of MS Centers, Paralyzed Veterans of America, National MS Society, and other health-care professional organizations. Her areas of research include the effects of body temperature and exercise, yoga and its effects on attention in aging and MS, and changes in functional performance of stroke patients and daclizumab.

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This increase puts San Diego at the top of the list of comparably sized metro areas in the DAWN report. Atlanta, for example, with a similarly sized population, had a 53.8 change in the 1994-2001. Among western cities, Seattle had the next highest increase behind San Diego, 81.9 percent from 1994 to 2001. The San Diego surgeon was a typical narcotic analgesic abuser, according to San Diego Police Detective Kevin Barnard, a 15-year department veteran and member of the San Diego Regional Pharmaceutical Narcotic Enforcement Team. First, he is white and middleclass. According to the National Institute on Drug Abuse, whites are more likely than other ethnic groups to abuse prescription drugs. Further, Barnard said, he was a licensed professional with a lot to lose socially, economically and emotionally by being arrested for drug use. Licensed professionals comprise a huge group of people, including physicians, nurses, physical therapists, veterinary technicians, pilots, hearing aid dispensers, chiropractors, engineers, barbers and beauticians, accountants, architects, dentists and dental assistants, surveyors, court reporters, optometrists and opticians, pharmacists, attorneys, psychologists, speech therapists--the list is vast. What they have in common is that a drug conviction jeopardizes their livelihood, as well as their social and family standing. Experts agree that most abusers of prescription drugs start out with legitimate prescriptions for pain--for example, after a root canal. The risk of developing dependence or addiction is small, according to NIDA, as long as patients take the medications as prescribed. But the risk for developing dependence on narcotic analgesics is real, according to David Thomas, who studies pain issues for NIDA. "People have been using opioids for thousands of years for pain, " Thomas said. "Although dependence can be likely, the chances of addiction are very low. The. Assive hemispheric infarctions constitute 5% of all ischemic strokes and have a mortality rate of 50% to 80%.1 The principal cause of death in patients with this "malignant middle cerebral artery syndrome" is focal brain edema, with resultant compartmental shift and cerebral herniation.2 Because of the high mortality rate and the poor functional outcome among survivors, aggressive therapeutic maneuvers have been considered for this catastrophe, including decompressive hemicraniectomy and induced hypothermia. Animal experiments and preliminary human studies suggest that both of these approaches may limit infarct size and improve mortality, particularly if instituted early after stroke onset.310 and dactinomycin.
Ported 6-month results for the first 4 patients who had undergone fetal mesencephalic transplantation according to this protocol.23 They experienced consistent clinical benefit and increased fluorodopa FD ; uptake on positron emission tomography PET ; . We now report the longer-term results of transplantation for the first 6 patients including the original 4 ; to undergo transplantation according to our protocol.

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Growths caused by strain MC29 are primary tumors of the kidney and liver 17, 30 ; . A further unusual influence of strain MC29 not shown by any other leukosis virus is the induction of rapid, massive mor phologic alteration of CEC2 in vitro 21 ; . Change is detectable as early as 48 hr, and the entire culture may be altered within and dalteparin.
Dacarbazine and procarbazine arecurrently approved drugs in the united states which act as alkylators of dna. Smoke is a beautiful buckskin color and a handy size for anyone. Extremely gentle for the whole family. Used on the ranch and broke so you can turn him out for a long time and he'll come back gentle for you and damiana.

J-53 Coping with Crises: How Providers Can Meet Reproductive Health Needs in Crisis Situations [2005] J-54 When Contraceptives Change Monthly Bleeding [2006] with supplement: Key Facts About the Menstrual Cycle ; INJECTABLES AND IMPLANTS--Series K K-4 Guide: Guide to Norplant Counseling [1992] F, S ; ORAL CONTRACEPTIVES--Series A K-5 Guide: Guide to Counseling on Injectables [1995] F, P, S ; A-9 Oral Contraceptives--An Update [2000] F, S ; K-5 Fact Sheet: DMPA at a Glance [1995] F, P, S ; A-10 Helping Women Use the Pill [2000] F, S ; ISSUES IN WORLD HEALTH--Series L INTRAUTERINE DEVICES--Series B L-10 Wall chart: Family Planning After Postabortion Treatment B-6 IUDs--An Update [1995] F, P, S ; [1997] F, P, S ; L-11 Ending Violence Against Women [1999] F, P, S ; B-7 New Attention to the IUD [2006] L-12 Youth and HIV AIDS: Can We Avoid Catastrophe? BARRIER METHODS--Series H [2001] F, P, S ; H-9 Closing the Condom Gap [1999] F, P, S ; L-13 Birth Spacing: Three to Five Saves Lives [2002] F, S ; FAMILY PLANNING PROGRAMS--Series J L-14 Better Breastfeeding, Healthier Lives [2006] J-39 Paying for Family Planning [1991] F, S ; with supplement: Breastfeeding Questions Answered: J-41 Supplement: Female Genital Mutilation: A Guide For Providers ; A Reproductive Health Concern [1995] F ; SPECIAL TOPICS--Series M J-42 Helping the News Media Cover Family Planning M-13 Winning the Food Race [1997] F, S ; [1995] F, S ; M-14 Solutions for a Water-Short World [1998] F, S ; J-43 Meeting Unmet Need: New Strategies [1996] F, S ; J-45 People Who Move: New Reproductive Health Focus M-15 Population and the Environment: The Global Challenge [2000] F, S ; [1997] F, S ; M-16 Meeting the Urban Challenge [2002] F, S ; J-46 Reproductive Health: New Perspectives on Men's M-17 New Survey Findings: The Reproductive Revolution Participation [1998] F, S ; Continues [2003] F, S ; J-49 Why Family Planning Matters [1999] F, S ; M-18 Men's Surveys: New Findings [2004] F, S ; J-50 Informed Choice in Family Planning: Helping People M-19 New Contraceptive Choices [2005] F, S ; Decide [2001] F, P, S ; J-51 Family Planning Logistics: Strengthening the Supply MAXIMIZING ACCESS AND QUALITY--Series Q Chain [2002] F, S ; Q-1 Improving Client-Provider Interaction [2003] F, S ; J-52 Performance Improvement [2002] F, S ; Q-2 Organizing Work Better [2004] F, S ; 1. q Send copies of each future issue of Population Reports. q I already on the Population Reports mailing list. q Send me a binder in developed countries, US.00 ; . 2. Language: qEnglish qFrench qPortuguese qSpanish.

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And God said, "See, I have given you every herb that yields seed which is on the face of all the earth, and every tree whose fruit yields seed; to you it shall be for food. Also, to every beast of the earth, to every bird of the air, and to everything that creeps on the earth, in which there is life, I have given every green herb for food". Genesis: 1: 29-30. Within this bequest of "herbs and fruits" is the medically important class of micronutrients called the flavonoids. Within this category, the soybean sticks out like a noble green thumb. The soybean was such a valuable part of Chinese medicine that the emperor Sheng-nung c. 2838 BC ; designated it as one of the "sacred crops". This appears well-justified considering there are more than 500 peer-reviewed articles on soy protein and its benefits in relation to cancer, heart disease, diabetes, osteoporosis, and renal disease. The PCRI website has a general review of "Soy and Green Tea Polyphenols". The current review focuses on IP and danaparoid.

15 For Ernst Cassirer, the value of art lies precisely in such dynamic interaction: "Aesthetic experience begins with a sudden change in my frame of mind. I begin to look at the landscape not with the eye of a mere spectator but with an artist's eye" from his "The Educational Value of Art, " 1943, as given in Verene, 1979, pp. 214215 ; . Art cannot be received in a passive way; Cassirer writes that "we have to construct, to build up these forms, in order to be aware of them, to see and feel them." It is this dynamic character of aesthetic experience that "gives to art its special place in human culture and makes it an essential and indispensable element in the system of liberal education" pp. 214215 ; . A growing body of work in philosophy and literary criticism is addressing the nature of the individual's complex responses to a work of art. See Bruner, 1986; Nussbaum, 1990; and Fleischacker, 1999. Nussbaum claims that great literature is better suited than philosophy itself to conveying "the value and beauty of choosing humanly well" 1990, p. 142 ; . Because literature actively involves us in the inner lives of characters that must make judgments in the face of complex circumstances and daunting uncertainties, we come to appreciate the difference between judging poorly and judging well. Like Nussbaum, Fleischacker describes aesthetic judgment as a complex skill that bridges the emotions and the understanding and is grounded in perception of the particulars of a situation. He argues that it is closely connected to both moral judgment and the practical reasoning that individuals use in interpreting their life experiences. He claims that these faculties, taken together, are the means by which individuals most fully express their freedom and individuality.

In Norway. In both cases the spillway was of the fured overflow type with a bridge supported by and dandelion.

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Experimental Oncology 27, 38-42, 2005 March ; the comet's tail. This hints to a general increased frangibility of the telomeric regions. By comparing the slopes of the linear regressions of the BLM and the BLM-cis-DDP treatment a slope of 1.07 was found for the BLM treatment alone, which indicates that the telomeres are of the same sensitivity as the average DNA. In contrast the treatment with the combination of BLM and cis-DDP results in a slope smaller than 1 b 0.77 ; and hints to an enhanced cross-linking effect on the telomere sequences and dacarbazine.

Mide can reverse the resistance to chloroethylnitrosoureas of a mouse L1210 leukemia. Anticancer Res. 11, 115 121. de Bono, J., Denis, L., Patnaik, A., Hammond, L., Geyer, C., Gerson, S., Cutler, D., Reyderman, L., Rowinsky, E., and Tolcher, A. 2001 ; Extended temozolomide TMZ ; dosing schedules permit the administration of higher TMZ dose intensities and inhibit the DNA repair enzyme O6-alkylguanine DNA alkyltransferase AGAT ; . Eur. J. Cancer 37, S31S32 abstract ; . Fine, H.A., Dear, K.B.G., Loeffler, J.S., Black, P.M., and Canellos, G.P. 1993 ; Metaanalysis of radiation therapy with and without adjuvant chemotherapy for malignant gliomas in adults. Cancer 71, 2585 2597. Folkman, J. 2003 ; Angiogenesis and apoptosis. Semin. Cancer Biol. 13, 159 167. Friedman, H.S., McLendon, R.E., Kerby, T., Dugan, M., Bigner, S.H., Henry, A.J., Ashley, D.M., Krischer, J., Lovell, S., Rasheed, K., Marchev, F., Seman, A.J., Cokgor, I., Rich, J., Stewart, E., Colvin, O.M., Provenzale, J.M., Bigner, D.D., Haglund, M.M., Friedman, A.H., and Modrich, P.L. 1998 ; DNA mismatch repair and O6-alkylguanine-DNA alkyltransferase analysis and response to Temodal in newly diagnosed malignant glioma. J. Clin. Oncol. 16, 3851 3857. Friedman, H.S., Kerby, T., and Calvert, H. 2000a ; Temozolomide and treatment of malignant glioma. Clin. Cancer Res. 6, 2585 2597. Friedman, H.S., Pluda, J., Quinn, J.A., Ewesuedo, R.B., Long, L., Friedman, A.H., Cokgor, I., Colvin, O.M., Haglund, M.M., Ashley, D.M., Rich, J.N., Sampson, J., Pegg, A.E., Moschel, R.C., McLendon, R.E., Provenzale, J.M., Stewart, E.S., Tourt-Uhlig, S., Garcia-Turner, A.M., Herndon, J.E., 2nd, Bigner, D.D., and Dolan, M.E. 2000b ; Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant glioma. J. Clin. Oncol. 18, 3522 3528. Gerson, S.L. 2002 ; Clinical relevance of MGMT in the treatment of cancer. J. Clin. Oncol. 20, 2388 2399. Gilbert, M.R., Friedman, H.S., Kuttesch, J.F., Prados, M.D., Olson, J.J., Reaman, G.H., and Zaknoen, S.L. 2002 ; A phase II study of temozolomide in patients with newly diagnosed supratentorial malignant glioma before radiation therapy. Neuro-Oncol. 4, 261 267. GMT. Glioma Meta-Analysis Trialists GMT ; Group. 2002 ; Chemotherapy in adult high-grade glioma: A systematic review and meta-analysis of individual patient data from 12 randomised trials. Lancet 359, 10111018. Jaeckle, K.A., Eyre, H.J., Townsend, J.J., Schulman, S., Knudson, H.M., Belanich, M., Yarosh, D.B., Bearman, S.I., Giroux, D.J., and Schold, S.C. 1998 ; Correlation of tumor O6 methylguanine-DNA methyltransferase levels with survival of malignant astrocytoma patients treated with bischloroethylnitrosourea: A Southwest Oncology Group study. J. Clin. Oncol. 16, 3310 3315. Levin, V.A., Uhm, J.H., Jaeckle, K.A., Choucair, A., Flynn, P.J., Yung, W.K.A., Prados, M.D., Bruner, J.M., Chang, S.M., Kyritsis, A.P., Gleason, M.J., and Hess, K.R. 2000 ; Phase III randomized study of postradiotherapy chemotherapy with N- 2chloroethyl ; -N'-cyclohexyl-N-nitrosurea, vincristine DFMO-PCV ; versus PCV for glioblastoma multiforme. Clin. Cancer Res. 6, 3878 3884. Macdonald, D.R., Cascino, T.L., Schold, S.C., Jr., and Cairncross, J.G. 1990 ; Response criteria for phase II studies of supratentorial malignant glioma. J. Clin. Oncol. 8, 12771280. Medical Research Council Brain Tumor Working Party 2001 ; Randomized trial of procarbazine, lomustine, and vincristine in the adjuvant treatment of high-grade astrocytoma: A Medical Research Council trial. J. Clin. Oncol. 19, 509 518. Mitchell, R.B., and Dolan, M.E. 1993 ; Effect of temozolomide and dacarbazine on O6-alkylguanine-DNA alkyltransferase activity and sensitivity of human tumor cells and xenografts to 1, 3-bis 2-chloroethyl ; -1nitrosourea. Cancer Chemother. Pharmacol. 32, 59 63 and dantrolene.

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