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Some people are taken aback by my race, " said Lemoine Jr. "But after they see how I practice medicine, it's not an issue. I still have people ask what race I on the phone." His father said he really didn't experience much racism but spent most of his time at Meharry, a historically black college, and associated primarily with his colleagues. Lemoine Sr. said no racism existed in Haiti and he really didn't notice or understand racism in America until he stopped at a Broadway restaurant in Nashville to make a telephone call in the early 1960s. "They looked at me very strange. I was ignorant of the culture. I was not American. I did not understand everything in American life. It was a struggle to me to understand, " he said. Lemoine Jr. said his mother was the "militant one" when it came to race relations and participated in the civil rights "sit-ins" at white lunch counters in downtown Nashville during the early 1960s. Raymonde Lemoine was head of the Meharry pediatrics department until she retired in the mid-70s to care for her daughter, who had become ill. Lemoine Jr. said changes in the medical profession have led most physicians to combine their offices into large group practices in order to cut costs. He's experienced the group-practice environment and vows to resist doing such in. Cox-2 inhibitors examples: celecoxib celebrex ; , valdecoxib bextra ; doctors had high hopes for this class of drugs for their patients who needed long-term pain relief. Five recent studies Petitti et al, 1996; World Health Organization Collaborative Study of Cardiovascular Disease and Steroid Hormone Contraception, 1996a; Schwartz et al, 1997; Heinemann et al., 1998; Lidegaard and Kreiner, 1998 ; have estimated the risk of ischaemic stroke associated with current use of low oestrogen dose OCs Table II ; . The risks were highest in the developing country centres participating in the WHO study, and lowest in the study conducted in women enrolled in the Kaiser Permanente Medical Care Program in California, a group of well-screened and carefully monitored women. The average risk was a 2.2-fold increase associated with OC use. Both the WHO and the Transnational studies demonstrated the importance of screening OC users before or during use to minimize any OC-associated adverse effects on risk of ischaemic stroke. The overall RR compared with non-users was 4.2 2.9-6.2 ; in women who did not report a blood pressure check before OC use, and 2.0 1.5-2.7 ; in those who reported a blood pressure check. If the RR estimates from the two USA and the Danish studies are combined with the other studies for users whose blood pressure was checked, the overall estimate of risk is 1.7 1.4-2.2 Improvement of photoaging but different degrees of irritation. Arch Dermatol 1995: 131; 1037. Since in vitro measurements of COX isoform selectivity may be unreliable predictors of in vivo activity, we directly assessed the effect of various doses of several NSAIDs and valdecoxib on PG content in vivo derived from either COX-1 gastric mucosa ; or COX-2 inflamed air pouch ; . This provided a quantitative biochemical assessment of the specificity of inhibition of COX isoforms in vivo. As shown in Figure 3, valdecoxib dose-dependently decreased inflammatory PGE2 production, with half maximal inhibition ED50 ; occurring at approximately 0.06 mg kg; little inhibition of COX-1 derived gastric PG content was observed over a wide dose range. In contrast, NSAIDs showed no specificity for either COX isoform meloxicam and nabumetone ; or apparent COX-1 specificity etodolac ; in this in vivo assay. Quantitative comparisons of several NSAIDs derived from dose-response analyses are shown in Table 1, panel 3.

TheAEC has now finallyacknowledgedthat the Z-plant is non-viableand hopelessly energy inefficient. Average energy consumption fQr centrifuge enrichment is quoted at 50 kWh SWU and 3000kWh SWU for diffusiontechnology. Theenergy consumption ofthe Z-plant has been estimated as 9200 kWhISWU. Theplant uses close to 200MW ofelectricity to produce fuelto power a 900MW nuclearreactorwhich is operatingat halfits design capacity kom supplies electricityfor the enrichment plant at slightly more thanmarginalcost. TheAEC undertakes separative work at internationalUSA Department ofEnergy DOE ; prices and the AEC'suraniuminventoryis sold to Eskom at historic cost. These are all substantiallyabove international spot market prices. The AEC has accepted that the Z-plant will have to be closed. It will cost about R20 million per annum for a numberofyears to decontaminate it. A new pilot-scale enrichment plant is being constructed, based on the molecularlaser isotope-separation MLIS ; process. Approximatly R30 million per annum is being spent on this project whose viability will be re-evaluated in March 1996 and will only be continued if a commercial partner is found. The AEC claims four bteakthroughsin its MLIS research: an efficient nozzle that allows extremely rapid cooling over fairly long distances of the incoming UF6 stream; the first industrialscale carbon dioxide laser; the first industrial-scale Raman cell; and a single-step enrichment processup to about 4%U235on amacro-scale. It is difficultto independently assessthese claims or potential commercial viability ofthe process--but some caution must be expressed given the AEC's past track record with 'breakthroughs' in enrichment technology. The USA, alone, has spent overa billion dollars on another and valganciclovir.

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