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Sung-Ja Ahn, M.D. , Young-Chul Kim , M.D. , Kyu-Sik Kim, M.D. , Kyung-Ok Park, M.D. , W oong-Ki 1 Chung, M.D. , Taek-Keun Nam , M.D. , Byung-Sik Nah, M.D. , Ju-Young Song, Ph.D. and Mi-Sun Yoon, 1 M.D. Departments of Radiation Oncology, Internal Medicine, Chonnam National University Medical School, Department of Internal M edicine, Seonam University M edical School, Gwangju, Korea.
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`No fear. They thought we didn't tumble, I expect; but I seen their horses hung up outside, both shod all round; bits and irons bright. Stabled horses, too, I could swear. Then the youngest chap -- him with the old felt hat -- walked like this.' Here he squared his shoulders, put his hands by his side, and marched up and down, looking for all the world like one of them chaps that played at soldiering in Bargo. `There's no hiding the military air, you think, Billy?' said Starlight. `That fellow was a recruit, and had been drilled lately.' `I d'no. Mother got 'em to stay, and began to talk quite innocent-like of the bad characters there was in the country. Ha! ha! It was as good as a play. Then they began to talk almost right out about Sergeant Goring having been away on a wrong scent, and how wild he was, and how he would be after Starlight's mob to-morrow morning at daylight, and some p'leece was to meet him near Rocky Flat. They didn't say they was the p'leece; that was about four o'clock, and getting dark.' `How did you get the horse?' says Jim. `He's not.
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An interesting parallel to observe here is with the wellknown mystic tendency in Benjamin's writings. This tendency is usually characterized by readers of Critical Theory as a sort of eccentricity, or even an outright shortfalling, of Benjamin, who is in this context thought to be overly influenced by Jewish theological traditions. I do not read it this way. I think Benjamin's mysticism is.
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To localize the UO-44 protein, controls and UO-transfected MCF-7 cells were grown to 90% confluence. Plasma membrane-enriched subcellular fractions and cytosol were prepared by differential centrifugation as described previously 21 ; . Plasma membrane and cytosolic proteins were subjected to Western blot analysis as described 22 ; . Blots were incubated with mouse anti-6-Histidine antibody Epitope Tagging ; Ab-1 NeoMarkers, Union City, CA ; 1: 500 dilution ; and horseradish peroxidase-conjugated donkey antimouse secondary antibody 1: 7500 ; . Blots were visualized with a chemiluminescent detection system ECL; Amersham Pharmacia Biotech ; and exposed to film for 10 45 sec and thiabendazole.
Since 1988, conducted many creative writing, playwriting, and songwriting workshops for West Virginia public school students, including two month-long residencies in all Jackson County elementary schools and one-day to two-week workshops in Fayette, Grant, Hampshire, Harrison, Kanawha, Lincoln, Morgan, Pocahontas, Putnam, Randolph, and Upshur counties. Conducted numerous workshops for women and girls at the Family Resource Center of Charleston Area Medical Center, and annual workshops for award-winning young writers during Young Writers Day at the University of Charleston. Workshop for teachers, "Make Your Own Folk Song: Songwriting with History, " presented several times at The Clay Center, Charleston. Currently conduct an annual weeklong songwriting workshop at Ghost Ranch in Abiquiu, New Mexico, with singer songwriter Julie Adams. Also with Adams, I have taught songwriting workshops for West Virginia University Women's Center, Michigan State University's ROIAL Residential Option In Arts & Letters ; program, and Garrett Community College MD ; . I have led several songwriting workshops at Kanwaha Valley FOOTMAD Friends of Old Time Music and Dance ; fall festivals.
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Ranbaxy has reached an agreement with GlaxoSmithKline to dismiss litigation over US patent No 4, 957, 924, which covers the active ingredient in the innovator's herpes shingles drug Valtrex valacyclovir; also named valaciclovir ; and is set to expire in June 2009. Ranbaxy claims that under the deal it will enter the US Valtrex generic market in late 2009, and that since it has firstfiler status it will be entitled to 180 days of market exclusivity. The branded Valtrex product has annual US sales of around .3 billion. Ranbaxy has also obtained a licence to two other GSK patents listed in the Orange Book: Nos 5, 879, 706 and 6, 107, 302. Ranbaxy is the only generic manufacturer to have made a paragraph IV challenge to GSK's `924 valacyclovir compositionof-matter patent, stating that it believes it does not infringe the Orange Book-listed patent, or that the patent is invalid or unenforceable. GSK sued Ranbaxy in May 2003 claiming infringement of the `924 patent, and the case has been winding its way through a district court in New Jersey. In February 2007, Ranbaxy won final approval of its ANDA and notified GSK that it planned to bring its generic product to market. GSK immediately said it would seek a preliminary injunction. Valacyclovir is an L-valyl prodrug of acyclovir, and in the `924 patent valacyclovir and its salts, including the hydrochloride salt, are among the disclosed compounds. Apart from Ranbaxy, Mylan and Watson Laboratories have also received FDA tentative approval to market generic valacyclovir.
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The combination of these methods appears to be helpful in selecting extracts of different polarities from plants for the presence or absence of sweet constituents and about 2 3 of the pure compounds tested that were known to be sweet to humans were evaluated as `sweet` to the gerbil. While the gerbil is not a perfect model for human sweet taste it does respond well to many bulk" i.e., sugars and polyols ; and intense" sweeteners, and the assay is more economic to perform than other in vivo options currently available.
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Adolescents face cultural, financial, legal, psychological, and social barriers to accessing contraceptive information and services, especially EC-related information and services. SAM asserts its support for increasing awareness of and improving timely access to EC for teens. Specifically, SAM recommends adolescent health care providers to: q Maintain the same degree of confidentiality when providing EC as when providing other reproductive and sexual health care.2 q Counsel all adolescent men and women about EC during acute and routine health care visits.2 q Provide all adolescent women with an advance EC prescription or medication to take home for future use.2 q Provide EC without requiring adolescent women to receive a pregnancy test, pelvic exam, Pap smear, or STI HIV test.2 q Develop protocols for telephone triage and prescribe EC over the telephone, whenever possible.2 q Counsel all adolescent women being treated for sexual assault about EC and offer them EC.2 q Support changing the status of EC from prescription-only to over-the-counter without an age restriction.2 and thiothixene.
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Patient 21, who had weak inhibition, achieved CR, whereas patient 18, who had strong inhibition, showed no response. R115777 treatment has differential effects on oncogenic and tumor survival pathways. The observations described indicate that inhibiting farnesylation is insufficient for responses in many patients, suggesting that the oncogenic and tumor survival pathways that drive the MDS malignant cells are dependent on protein farnesylation in only some patients. Previously, we showed in cultured human cancer cells that FTI-induced apoptosis depends on the ability of these agents to suppress the phosphatidylinositol 3 kinase PI3K ; Akt pathway.35 We, therefore, determined the ability of R115777 to modulate PI3K Akt phosphorylation and other signaling pathways. To this end, we processed PBMCs for SDSPAGE immunoblotting with antibodies against total and phosphorylated forms of Akt, Erk1 2, STAT3, and -actin see "Patients, materials and methods" ; . Although attempts were made to analyze the effects of R115777 on these pathways in all patients, quantity or quality of the processed samples allowed us to report on only 5 patients, probably because many had very low blood counts. The results showed that all 3 PBMC pathways were not activated in many patients. In addition, R115777 treatment affected these pathways differentially. In patients 7, 14, and 17, R115777 treatment did not affect phospho-Akt or phospho-STAT3 levels Figure 5 ; . Phospho-Erk1 2 levels were low to undetectable. Figure 5 also shows that in patients 12 and 18, R115777 treatment resulted in an increase in phospho-Akt, total Akt, phospho-STAT3, and total STAT3 but did not alter total Erk1 2 and -actin levels. The increase in phosphorylated Akt and STAT3 was proportional to and, therefore, probably the result of the increase in total Akt and STAT3. As with FTase activity and HDJ-2 farnesylation, there was no obvious correlation between R115777 clinical activity and its ability to modulate these pathways.
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Nothing contained herein shall prevent MRS from invoking any remedy available in law or in equity including the bringing of an action in the nature of an interpleader in a court of competent jurisdiction. 13. OWNERSHIP OF PLANT AND EQUIPMENT. All equipment, plants, buildings, facilities, structures and other improvements of whatsoever kind or nature used by MRS in its operations or constructed or placed by MRS on the Premises shall be and remain the property of MRS during the term of this Lease. In the event of termination of this Lease as to any part of the Premises, MRS shall have the right to enter upon the Premises and remove from the Premises subject to such termination all of MRS's improvements and property of whatsoever kind situated thereon. Such right shall continue for a period of one year from and after the date of such termination and as long thereafter as MRS is diligently removing its said improvements or property. Any such improvements or property not removed or being diligently removed by MRS by the end of said period shall be deemed the property of Lessor, but MRS makes no warranties or representations regarding the condition of such improvements or property. MRS shall remove all buildings and structures that Lessor requests not be left on the Premises. 14. MRS'S RIGHT OF TERMINATION. MRS may, at any time or from time to time, during the Term of this Lease terminate this Lease in whole or in part by delivering to Lessor or to the office of the recorder of the County ies ; in which the Premises are situated a conveyance in recordable form surrendering and quitclaiming to Lessor all or any portion of the Premises. Upon such delivery, this Lease shall terminate with respect to the Premises described in such conveyance, and MRS shall be relieved of all obligations, liability or responsibility in respect to the Premises surrendered and quitclaimed to Lessor, save those obligations and liabilities incurred prior to surrender. Said conveyance surrendering and quitclaiming the Premises, or a portion thereof, shall be deemed to have been delivered to and received by Lessor or by said County recorder s ; upon the posting thereof in the United States mails when mailed certified or registered, postage prepaid, return receipt requested, or upon receipt when hand-delivered. 15. LESSOR'S RIGHT OF TERMINATION. Lessor shall be entitled to terminate this Lease upon the failure of MRS to make payment of any amount of money due and payable by MRS to Lessor pursuant to this Lease or upon the failure of MRS to keep or perform any other covenant or obligation on its part set forth herein; provided, however, that prior to terminating this Lease, Lessor shall first give to MRS written notice of MRS's default, specifying the circumstances thereof and the amount of money which Lessor claims is due and payable by MRS or the specific nature of any other claimed default. MRS shall have a period of sixty 60 ; days from and after receipt of said notice of default in which to cure same, or, in the event that such default cannot be cured within sixty 60 ; days, MRS shall commence to cure within such time, and shall continue to diligently pursue such cure, failing which Lessor may terminate this Lease by notice to MRS; provided further, however, that in the event MRS shall dispute the existence of a default on the part of MRS, MRS shall not be deemed in default unless and until there has been a final nonappealable judgment entered in writing by a court of competent jurisdiction in favor of Lessor. In the event of such judgment, MRS shall have a period of thirty 30 ; days after such entry of judgment in which to cure the default so adjudged, or, in the event such default cannot be cured within such thirty 30 ; day period, MRS shall commence to cure within such time, and shall continue to diligently pursue such cure, failing which Lessor may terminate this Lease by notice to MRS. 8 and thorazine.
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Configuration. According to Corollary 3.3, this configuration must be ordinary -- that is, it is constructed of two disjoint astral [2s, 2t]1 subconfigurations. Color one of the subconfigurations black and the other subconfiguration red. Consider a point in the special class of points in the [2s, 2t + 1]2 configuration; it must have 2s lines passing through it, two from each of the s symmetry classes of lines, and suppose the s symmetry classes of lines correspond to spans a1 , a2 , . symmetry, the lines passing through the special point either are all red or all black, or there are s black lines and s red lines passing through it. Case 1: Without loss of generality, say all the lines are black; then the black configuration together with the members of the special class which also have all black lines passing through them forms an astral [2s, 2t + 1]1 configuration, as does the red configuration with the rest of the special points, so together the black and red configurations with the special class of points forms an ordinary [2s, 2t + 1]2 configuration. Case 2: There are s black lines and s red lines passing through the point. Since there must be two lines of each of the spans a1 , a2 , . passing through the point, symmetry forces that there must be black lines of each span a1 , a2 , . and red lines of each span a1 , a2 , . passing through the point, Thus, the black lines of span a1 , a2 , . intersect to form an s-embryonic point, so the [2s, 2t + 1]2 astral configuration may be constructed as a mixed configuration using that s-embryonic point and thalidomide.
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