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The following members were left out of the listing of March 2005 Retirees. We apologize for the oversight. Name Rank District Years Olson, John C. Officer 012 32 Sak, James Officer 012 32 Seafranowski, Stanley T. Officer 140 37 Zaprzal, Lawrence Detective 650 34.
1.- In relation to the age and sex In Group A N 127 ; 85 cases 66.9% ; corresponded to female and 42 33.1% ; to male patients. In this group the relationship female-male was almost 2: 1. The average age in Group A at the moment of diagnosis of the ONJ was 65.6 years, with a minimum of 36 and a maximum of 89 years. The average age of female patients was 65.3 years range 36-89 ; and 66.1 years range 45-85 ; for the male patients. Surprisingly in the review presented by Marx et al. Group B ; 5 ; no references appear related to sex or the age of the patients. 2.- In relation to the type of BPP and the previous pathology From the different types of BPP associated with ONJ in Group A N 127 ; , the most common was pamidronate in 54 patients 42.5% ; , followed by the combination of pamidronate and zolendronic acid in 31 24.4% ; and zolendronic acid in 29 22.8% ; . Alendronate was associated with 9 patients 7.1% ; and ibandronate and risedronate in 1 patient 0.8% ; respectively. The combination of alendronate and zolendronic acid was used in 2 patients 1.6% ; . The main data concerning patients of Group A who took alendronate are shown in Table 1. In Group B 5 ; the most frequently associated BPP was zolendronic acid in 40.3% of the patients, followed by those who started their treatment with pamidronate and then changed to zolendronic acid in 30.2%, 26% of the patients with pamidronate and 2.5% with alendronate.
Between 1989 and 2002, 41 patients were referred for PA banding to train the mLV. Two groups were defined Table 1 ; . No patients had anomalies associated with sufficient pressure or volume load to condition the mLV.
Distribution the mean ± sd body retention of pamidronate was calculated to be 54 ± 16% of the dose over 120 hours.
Ver the last three years there have been a number of papers linking the aminobisphosphonates with osteonecrosis of the jaw ONJ ; . While 95 per cent of these reports relate to high dose intravenous IV ; aminobisphosphonates zoledronic acid [Zometa; Novartis Pharmaceuticals, East Hanover, NJ] and pamidronate [Aredia; Novartis Pharmaceuticals, East Hanover, NJ] ; used in oncology patients, there have also been a few reports relating to the oral aminobisphosphonate, alendronate Fosamax; Merck Co, West Point PA ; 1, 2, 5, ; . result of these reports, the manufacturer of zoledronic acid and pamidronate, Novartis, has issued guidelines for managing patients dentally 3 ; . Included in these guidelines is the recommendation.
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P-106S: ISOLATION OF MELANOGENESIS INHIBITORS FROM SAUSSUREAE RADIX Ji-Young Choi, Seung-Ho Lee College of Pharmacy, Yeungnam University, Gyeongsan 712-749, Korea Saussureae Radix Compositae ; has been traditionally used for lack of appetite, alleviating pain in abdominal distention and tenesmus, indigestion with anorexia, dysentery, nausea and vomiting. The constituents of S. Radix include sesquiterpenes, polyene alcohols, triterpenes, lignans, alkaloids and tannins. Fourteen compounds were isolated from the EtOAc soluble part of MeOH extract of S. Radix and tested for their melanin polymer synthesis inhibitory effect. Their chemical structures were identified as 1, 8, 11, ; , costunolide 2 ; , dehydrocostuslactone 3 ; , 11, 13-dihydrocostunolide 4 ; , reynosin 5 ; , 1-hydroxy arbusculin A 6 ; , -sitosterol 7 ; , heptadec- 9Z ; -enoic acid 8 ; , linoleic acid methyl ester 9 ; , mokko lactone 10 ; , -costol 11 ; , betulinic acid methyl ester 12 ; , betulinic acid 13 ; and daucosterol 14 ; by comparison of physical and spectral data with those reported in the literature. Among the isolated compounds, costunolide 100% ; , reynosin 100% ; , and 1hydroxy arbusculin A 92% ; showed potent inhibitory effects on melanogenesis in IBMX induced B-16 mouse melanoma cell lines and papaverine.
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Alendronate, risedronate, ibandronate, etidronate, clodronate, zoledronic acid, or pamidronate , scientists writing in the journal clinical therapeutics report.
Pamidronate was well tolerated; femoral neck fractures occurred in 2 subjects with severe local paget's disease but were unlikely to be due to the drug and parnate.
| Pamidronate medicationImproved Survival Among American Indian And Alaska Native AI AN ; Infants In The Pacific Northwest NW ; , 1984-97: A Closer Look At An Uncommon Narrowing Of An AI AN-White Child Health Disparity James A. Gaudino, Jr. * Background: Most AI AN infant mortality rates, IMRs, remain higher than white rates. The Northwest Portland Area Indian Health Board NPAIHB ; , serving 42 tribes, CDC and the Washington, Oregon, and Idaho health departments investigated AI AN infant survival. Methods: NPAIHB completed linking computerized birth certificate and birth-death files. We used death and birth cohorts, StatXact and SAS to compare 3-state resident, single and multi-year IMRs, basing infant race on mother's race, regardless of Hispanic origin. CDC's National Infant Mortality Surveillance ICD-9 categories were used for cause-specific rates. Results: Among 2.6 million records, there were 2100-2800 AI AN births annually. From 1984-1990, AI AN IMRs were 1.8-2.4 fold higher than white rates. AI AN IMRs dropped significantly from 21.6 per 1000 births in 1990 to 6.0 in 1995, nearly crossing the 5.5 1995 white rate. Compared to the 1995-97 rate, the 1998 rate increased to 10.3, with borderline significance. AI AN SIDS and respiratory distress syndrome rates significantly decreased, respectively, from 8.1 in 1984-87 to 2.3 in 1994-96 and from 1.8 in 1984-87 to 0.3 in 1991-93, then leveled off. "Other perinatal conditions" and "birth trauma, hypoxia and asphyxia" rates apparently, not significantly increased since 1997. Significant rate declines occurred among most demographic, risk behavior, birthweight, gestationalage, reproductive risk, birth spacing, labor delivery and obstetrical procedure sub-groups. Some AI AN sub-groups, e.g., Idaho residents, with no prenatal care and with 0-5 month spacing, experienced no improvements. Conclusions: These uncommon rate declines imply multi-factorial improvements among Northwest AI ANs. Community-level surveillance and interventions before conception through post-partum may further improve health.
Jrgensen. F.B. V. Syinbiutk N. fixation ia grass-ctuwer naxtaies in organic farming systems. NonJisk JunJhrugsairrkaiag. hUF-scnaaar analogical Nitrogen Fixation m Scandumvian Agrkuhanc. Risu. 26-28 May 1994. Jrgensen. RB. Geaspaedaiag fra raps fBrmskm aajnj til agerkl B. ivmpestnst - et ukrudt i agn * ufcojyudsactaiag af gi'wtii'fc modi fin, ridt phancr "NordftisfcGea". MHjusryrclsca. 21 Jul 1994. Jrgensen. K.B. Sauasaacous hybnditBihm heraecu oilseed rape Brmsicn nuaust aad weedy relatives. Nuan Crucifer Generics Workshop. Lisboa. Punugal. IS N m 1994. JCtars. A. Wvfnnnits. L. EU. 5.E. McLamghbn. W.L. Miller. A. Radialina chcancal reactions af niahenyl-lenaBuhani chloride in band aad sutid stale. M i nanny" S mpiiiiam on Bntnrioa Chcaustry. Haaganan Chemical Society. Bahnon szeptafc. Hungary. 3 4 Sep 1994. Katiks. A. Slczsak. I. McLaughkn. W.L. Hitler. A. QjciUomelric and amductiunelric analy'iir of aqueous and organic dm nm air siwutkms. 9 a Imcrnananal Milling oa Radiation Processing. Istanbul. Turkey. 11-16 Sep 1994. Kanzmurf. H. Non-destructive gammi n ; Pb-210 and ment accunnnanon rates. ENAM workshop. Lisbon 10-12 Mar 1994. Lange. C. Roed. J. Brrne. M . Gaddanl. A.H.J. Skin Deposition Measured with Avirvatahtc Tracers. NOSA Acnisoi Symposium ia Lund. Sweden. 20-21 Oct 1994. Larsen. J. Jakobsen Thingsirwp Rosendahl. S. Benomyl inhibits nypbal P transpon but nm fungal alkaline phiisphauscs in a cwcuadn.r-G'fnmw.1 culeoniwn symbiosis. Fourth European Symposium on Mycorrhizas. Granada. 11-14 Jul 1994. Linde-Laursen. I. Cytofaxonomy and evolution in die genus Hrdeam. Kew Chromosome Conference IV. Royal Botanic Gardens. Kew. England. I Sep 1994. Langva O. Cato . Kmzendvrf H. Kmjpers A. Dennegaard B. and Schroder H. Large scale dispersion of heavy-metal enrkbed sediments in the eastern Skagerrak and northern Kattegat. The North Sea Quality Status Report. Ebeltoft. 18-21 Apr 1994. Poster. Lyngkjirr. M. stergrd H. Munk L. Papilla formation in leaves of Mkt-rcsistaM barley attacked by Mkv virukiM powdery mildew. 3rd Cereal Mildew workshop Cost-Action 817 ; . Kappel AHVS. 5-10 Nov 1994. McLaughlin. W . Puh I. J.M. Miller. A. Temperature and relative humidity dependence of radiochromk film dosimeter response to gamma and electron radiation. 9th International Meeting on Radiation Processing. Istanbul. Turkey. 11-16 Sep 1994 and paromomycin.
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N 18 § n 19 in a randomized phase iii clinical trial, zoledronic acid was demonstrated to be as safe and effective as pamidronate for the treatment of bone metastases in patients with breast cancer and multiple myeloma.
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Background. SAPHO syndrome is increasingly recognized within the paediatric population. Conventional therapeutic approaches have often not been effective. Pamidronate is a second-generation bisphosphonate that affects bone turnover and demonstrates anti-inflammatory properties. In small case series it has given symptomatic relief to adults with this condition. Objectives. To report the clinical experience with pamidronate in childhood SAPHO syndrome. Methods. A retrospective observational study of all children with SAPHO syndrome treated with pamidronate between 1996 and 2003 at a tertiary rheumatology centre. The standard dosing regime for pamidronate was 1 mg kg to a maximum of 30 mg, administered daily for three consecutive days, repeated 3-monthly as required. Response to treatment was determined by clinical observation, patient subjective response and reduction in other treatments Results. Seven girls were treated, with a median range ; age at diagnosis of 11 yr 915 yr ; . All patients demonstrated a beneficial clinical response, with relief of pain, increased activity and improved well-being. Subsequent courses of pamidronate were used in all patients. Other medications including corticosteroids and methotrexate could subsequently be stopped. Transient symptoms were associated with the initial course of pamidronate in some patients. No serious adverse events were reported. Conclusions. Pamidronate was associated with a marked improvement in function and well-being, and a reduction of pain and use of other medications in all patients, with no significant adverse effects. This study represents preliminary clinical data. A prospective multicentre study is necessary to assess the role and long-term safety of pamidronate in the management of childhood SAPHO syndrome.
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A skin disease has been of major significance to the captive population and an outbreak that occurred in 1989 threatened the success of the captive breeding project. Less severe outbreaks occurred in 1990 and 1993, with isolated cases in between. In 1995 another outbreak affected a group of captive animals that was due to be released into one of the reserves. Affected tortoises initially had areas of dead, flaky skin around a white, caseous crust. The feet were most often affected and became swollen and the claws soft and brittle. In some animals lesions occurred on the relatively soft areas of skin between the scutes of the shell and on skin of the neck, head, legs and tail. The lesions often occurred without evidence of preceding trauma or obvious causative factors. If left untreated, tortoises first became lethargic and anorexic, and the disease was fatal in hatchlings and juveniles. Death was attributed to secondary septicaemia. Necropsy and culture of lesions performed at the Western Australian Department of Agriculture consistently yielded unidentified Pseudomonas sp, and histological examination demonstrated a severe, subacute to chronic ulcerative dermatitis. In some cases presumed secondary fungal hyphae were also demonstrable in surface serocellular crusts. Mader7 reported that Pseudomonas is perhaps the most common bacterial pathogen of reptiles and is commonly isolated from skin lesions, especially necrotising dermatitis. This is an opportunistic bacterium that part of the animal's normal microbiota and is ubiquitous in the western swamp tortoise ponds. Cooper8 encountered sudden outbreaks of Pseudomonas infections in reptile collections where the organism has been known to be present for a long period without any evidence of disease. In such cases, stressors involved are often unclear; rapid changes of ambient temperature or the introduction of a new member to the handling staff may be relevant. Cooper8 also claimed that skin lesions in captive reptiles may follow exposure to suboptimal temperature or humidity. The hatchlings from year 1989 were raised indoors for the first 4 to 5 months and were in poor general health and suffered from problems such as swollen eyelids.9 Stress associated with this ill health may have precipitated the skin disease. After poor success with the first batch of hatchlings in 1989 only 4 of 11 have survived to 1998 ; many adjustments were made in the management of the tortoises to improve their health and breeding success.9 The most notable changes were in relation to the diet and the rearing environment of hatchlings, which are now kept in outdoor enclosures from their first day. 9 Skin disease became less severe, suggesting that previous occurrences.
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Ctober 17, 1994, was my birthday I turned 49 years old. It was also the day my doctor told me I had multiple myeloma. My daughter, Melissa, searched the Internet for information about this little-known disease. That is when she found the International Myeloma Foundation and ordered the IMF InfoPack. Shortly thereafter, our family attended an IMF Patient & Family Seminar. We found ourselves on a steep learning curve and needed to do all we could to enhance our level of education about this disease. The information provided by the IMF was invaluable. At that time, melphalan and prednisone was considered to be the "Gold Standard" of myeloma treatment. After eighteen months on this chemotherapy regimen, plus six more months of self-administered shots of Interferon, I was told that the indicators for myeloma were so low that I was "almost in remission." Throughout my treatment, I continued to teach for the local school system. In addition, I returned to college and obtained a Masters Degree in 1997. In 1998, blood work indicated that the myeloma was staging a comeback. I was put back on melphalan and prednisone for another six months of treatment. In July of 1999, with myeloma on the rise once more, I headed to the University of Arkansas for Medical Sciences UAMS ; , together with my husband, Gilbert, and daughter, Jennifer. Doctors at UAMS first recommended a stem cell transplant but, when I resisted, proposed that I become part of a study involving thalidomide, an old drug that was new to myeloma therapy. I elected to join the study. I also received monthly infusions of Aredia pamidronate ; , a bisphosphonate to strengthen my bones. Thankfully, I responded to my new treatment regimen. I continued in the study until March of 2004 when, while on a trip back to UAMS, I fell and fractured my left 0 and pegasys.
Agonists. Constitutive activity of receptors has been explained by allosteric models in which receptors exist in spontaneous equilibrium between active and inactive conformations that are stabilized by agonists and antagonists, respectively. In this context, drug efficacy and potency are interrelated because they both depend on the same parameters, namely the absolute and relative affinities of a compound for receptors in active and inactive states and the ratio and concentrations of receptors in active and inactive states. All of our data are consistent with this model, in which raising G protein levels favors formation of the active conformation of receptors. Based on our findings, regulation of G protein concentration may be an important means of controlling receptor activity in vivo. These results define the functional relationship between G protein levels and muscarinic receptor pharmacology and pamidronate.
L. S. Kaminsky corresponding author ; , B , B . Hons., Ph.D., Wadsworth Center for Labs and Research, Empire State Plaza, New York State Department of Health, P. O. Box 509, Albany, NY 122010509. M. C. Mahoney, B.A., M.S., Ph.D., J. F. Leach, B.A., M.S., J. M. Melius, A.B., M.M.S., M.D., Dr. P.H., and M. J. Miller, B.A., M.S., New York State Department of Health, Albany, New York and pegfilgrastim.
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There is a growing understanding of the extent of hepatitis C infection in the Australian community. With this comes a greater understanding of the natural progression of hepatitis infection and the role of treatment. We know that a significant number of people clear the virus and that, at varying rates, some people who experience disease require treatment. Two-drug therapy using interferon and ribavirin is now seen as optimal for those who require treatment. Treatment with both drugs is two to three times better than treatment with interferon alone. And there is hope that more efficacious treatments may be developed. Likewise formulation can impact on efficacy; pegylated interferon is taken less frequently which reduces side effects in many people. Interferon and ribavirin are both listed under section 100 of the National Health Act. Section 100 allows the federal health minister to subsidise the purchase of highly specialised and high cost drugs. Other drugs which are funded this way include many of the chemotherapy drugs used in the treatment of cancer; drugs to prevent rejection of organs following transplant; antipsychotics such as clozapine; the antiretroviral drugs used to treat HIV infection and a number of the drugs used in the management of opportunistic infections associated with advanced HIV disease. In short, s100 listing means that the Commonwealth pays for these drugs when they are prescribed by a specialist via the public system rather than the state health department or area health service having to meet the cost as they do with other drugs dispensed in hospital ; . State Health Departments are responsible for administering the programs. There are a couple of exceptions to this. Firstly, the program was recently expanded to include private hospitals. This arm of the program is administered by the Commonwealth. The other exception relates to HIV treatments where access to prescribing has been expanded to general practitioners who, with appropriate training and support, are seen as a type of quasi-specialist. When prescribing, these doctors act like agents of the public system. General practitioners do not currently have access to interferon and ribavirin prescribing. Treatment with these drugs lasts for between six and twelve months. A number of shared care strategies have been piloted but as yet I do not believe any have passed beyond the trial phase. Consumer advocates see total reliance on public liver clinics as very problematic for patients because: A number of remedies have been suggested to improve access and each of these needs to be explored. Given the very significant differences between various Australian locations it is unlikely that any one remedy will suit all settings. There may be a number of alternative suggestions.
Generally recognized as safe and effective and not misbranded: drugs used in research. Fed Reg 1990; 21: 200-205. McAfee JG, Subramanian 0. Interpretation of interspecies differences in and pegvisomant.
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Infusion [12, 30, 31]. Subsequently, pamidronate was shown to be safe and effective for the treatment of HCM when administered as a 2-hour i.v. infusion [28]. Moreover, two randomized, comparative trials found that a single infusion of 60 mg pamidronate was more effective than multiple infusions of etidronate 7.5 mg kg i.v. daily 3 days ; [30] or clodronate 1, 500 mg ; [26] for the treatment of HCM. Based on these data, i.v. pamidronate 60 or 90 mg, depending on baseline serum calcium levels ; became the preferred agent for the treatment of HCM. These studies established that bisphosphonate therapy could be safely administered as a 2-hour i.v. infusion in the outpatient setting, which has since become the standard in most countries because costs are lower and patients are less inconvenienced than with a 24-hour infusion. IBANDRONATE Intravenous ibandronate also has demonstrated efficacy in the treatment of HCM and has received regulatory approval in Europe for this indication. Single doses of ibandronate ranging from 0.2-6 mg via 2- to 4-hour infusions have been investigated in trials involving more than 300 patients [12]. A dose of 4-6 mg ibandronate via a 2-hour infusion ; was required to effectively normalize serum calcium levels in 75%-80% of patients with moderate-to-severe HCM serum calcium 12 mg dl ; [36]. Serum creatinine elevations were reported in 1% of patients treated with ibandronate in those studies [12]. The safety of a single i.v. bolus infusion of 3 mg ibandronate in patients with normocalcemic breast cancer has also been investigated in a small pilot study; however, transient proteinuria occurred in almost half the patients and was sometimes associated with leukocyturia and microhematuria [17]. Additionally, this regimen was associated with a high incidence of serum divalent ion depletion 67% hypocalcemia and 53% hypophosphatemia ; . The administration of i.v. bolus ibandronate at higher doses or in patients with HCM has not been investigated and is not recommended. Therefore, the use of 6 mg ibandronate to treat HCM requires an infusion time 1 hour [37]. ZOLEDRONIC ACID Zoledronic acid is a new-generation, highly potent, nitrogen-containing bisphosphonate that is at least 100-fold more potent than pamidronate in preclinical models of osteoclastmediated bone resorption [38] and roughly an order of magnitude more potent than ibandronate at inhibiting signal transduction pathways in osteoclasts [39]. Zoledronic acid has gained worldwide regulatory approval for the treatment of HCM based on data from two large, randomized trials demonstrating the safety and superior efficacy of 4 or mg zoledronic acid, compared with 90 mg pamidronate [1]. Those trials enrolled 287 patients with moderate to severe HCM and papaverine.
Treatment with pamidronate and zoledronate might be a determining factor in oncological patients suffering from mandible and maxilla bone necrosis. - A surgical performance carried out by oral and maxillofacial surgeons, stomatologists and odontologists might lead to bone exposure. -It is a pathology difficult to treat, in patients who usually have a previously limited quality of life. -A treatment based on conservation and as harmless as possible seems to be the most advisable way of acting with these patients. -Further research will be essential to clarify the cause, minimize the incidence and register the treatment, once the lesions have been ascertained and pemetrexed.
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