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Why Patients Drop Psychotherapy: A Look at Childhood Trauma in Patients with Bulimia Nervosa . Young Bones and Anorexia Nervosa.
C. Zamudio1, C. Seas2, K.Hernandez1, E.Ramos3, K. Verdonck4, P. Legua2, J. Echevarria2, C. Maguina2, E. Gotuzzo2. 1Universidad Peruana Cayetano Heredia, Lima, Peru; 2Universidad Peruana Cayetano Heredia.Hospital Nacional Cayetano Heredia.Instituto de Medicina Tropical "Alexander von Humboldt, " Lima, Peru; 3Henry Ford Hospital, Detroit, Michigan, USA; 4 Prince Leopold Institute of Tropical Medicine, Antwerp, Belgium.
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| Depletion of olfactory bulb serotonin by 5, 7-dihydroxytryptamine 5, ; is said to result in a progressive hyposmia and, within 28 days of treatment, in virtual anosmia Moriizumi et al., 1994, Neuroscience, 61: 733 ; . To further assess this we tested pre-operatively trained rats on an odor detection task and four progressively more difficult odor mixture tasks. An olfactometer was used and rats were tested 14, 21, 28 and 35 days after bilateral injections of saline or 5, 7-DHT into the olfactory peduncle. As determined by immunohistochemistry, 5, 7-DHT produced severe depletion of olfactory bulb serotonin. In behavior tests, experimental rats performed as well as controls in the first 28 days after treatment but on day 35 performed more poorly on the most difficult of the odor mixture tasks. We conclude that severe depletion of olfactory bulb serotonin does not result in anosmia but may produce a gradual decrease in odor sensitivity and olmesartan.
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This work was supported by Grant NIDDK 38106-11 from the National Institute of Diabetes and Digestive and Kidney Diseases. The health economic analysis was supported by an independent contract to Covance from Novartis Pharmaceuticals Corp. 19.
Recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. N Engl J Med 321: 17971803 Cummings DE, Merriam GR 2003 Growth hormone therapy in adults. Annu Rev Med 54: 513533 Cook DM, Biller BM, Vance ML, Hoffman AR, Phillips LS, Ford KM, Benziger DP, Illeperuma A, Blethen SL, Attie KM, Dao LN, Reimann JD, Fielder PJ 2002 The pharmacokinetic and pharmacodynamic characteristics of a long-acting growth hormone GH ; preparation nutropin depot ; in GHdeficient adults. J Clin Endocrinol Metab 87: 4508 4514 Bright GM, Veldhuis JD, Iranmanesh A, Baumann G, Maheshwari H, Lima J 1999 Appraisal of growth hormone GH ; secretion: evaluation of a composite pharmacokinetic model that discriminates multiple components of GH input. J Clin Endocrinol Metab 84: 33013308 Reiter EO, Attie KM, Moshang Jr T, Silverman BL, Kemp SF, Neuwirth RB, Ford KM, Saenger P 2001 A multicenter study of the efficacy and safety of sustained release GH in the treatment of naive pediatric patients with GH deficiency. J Clin Endocrinol Metab 86: 4700 4706 Underwood LE, Attie KM, Baptista J 2003 Growth hormone GH ; doseresponse in young adults with childhood-onset GH deficiency: a two-year, multicenter, multiple-dose, placebo-controlled study. J Clin Endocrinol Metab 88: 52735280 Hoffman AR, Kuntze JE, Baptista J, Baum HB, Baumann GP, Biller BM, Clark RV, Cook D, Inzucchi SE, Kleinberg D, Klibanski A, Phillips LS, Ridgway EC, Robbins RJ, Schlechte J, Sharma M, Thorner MO, Vance ML 2004 Growth hormone GH ; replacement therapy in adult-onset GH deficiency: effects on body composition in men and women in a double-blind, randomized, placebo-controlled trial. J Clin Endocrinol Metab 89: 2048 2056 Montague CT, O'Rahilly S 2000 The perils of portliness: causes and consequences of visceral adiposity. Diabetes 49: 883 888 Wolthers T, Hoffman DM, Nugent AG, Duncan MW, Umpleby M, Ho KK 2001 Oral estrogen antagonizes the metabolic actions of growth hormone in growth hormone-deficient women. J Physiol Endocrinol Metab 281: E1191 E1196 Simpson H, Savine R, Sonksen P, Bengtsson BA, Carlsson L, Christiansen JS, Clemmons D, Cohen P, Hintz R, Ho K, Mullis P, Robinson I, Strasburger C, Tanaka T, Thorner M 2002 Growth hormone replacement therapy for adults: into the new millennium. Growth Horm IGF Res 12: 133 Hoffman AR, Ceda GP 2004 IGFs and aging: is there a rationale for hormone replacement therapy? Growth Horm IGF Res 14: 296 300 Hoffman AR, Strasburger CJ, Zagar A, Blum WF, Kehely A, Hartman ML 2004 Efficacy and tolerability of an individualized dosing regimen for adult growth hormone replacement therapy in comparison with fixed body weightbased dosing. J Clin Endocrinol Metab 89: 3224 3233 Johannsson G, Marin P, Lonn L, Ottosson M, Stenlof K, Bjorntorp P, Sjostrom L, Bengtsson BA 1997 Growth hormone treatment of abdominally obese men reduces abdominal fat mass, improves glucose and lipoprotein metabolism, and reduces diastolic blood pressure. J Clin Endocrinol Metab 82: 727 734 Kamarudin N, Hew FL, Christopher M, Alford J, Rantzau C, Ward G, Alford F 1999 Insulin secretion in growth hormone-deficient adults: effects of 24 months' therapy and five days' acute withdrawal of recombinant human growth hormone. Metabolism 48: 13871396 Rosenfalck AM, Maghsoudi S, Fisker S, Jorgensen JO, Christiansen JS, Hilsted J, Volund AA, Madsbad S 2000 The effect of 30 months of low-dose replacement therapy with recombinant human growth hormone rhGH ; on insulin and C-peptide kinetics, insulin secretion, insulin sensitivity, glucose effectiveness, and body composition in GH-deficient adults. J Clin Endocrinol Metab 85: 4173 4181 Riedl M, Ludvik B, Pacini G, Clodi M, Kotzmann H, Wagner O, KautzkyWiller A, Prager R, Luger A 2000 The increased insulin sensitivity in growth hormone-deficient adults is reduced by growth hormone replacement therapy. Eur J Clin Invest 30: 771778 Svensson J, Fowelin J, Landin K, Bengtsson BA, Johansson JO 2002 Effects of seven years of GH-replacement therapy on insulin sensitivity in GH-deficient adults. J Clin Endocrinol Metab 87: 21212127 Knoepfelmacher M, Jallad RS, Liberman B 2003 Absence of effects of longterm growth hormone replacement therapy on insulin sensitivity in adults with growth hormone deficiency of childhood-onset GHDA-CO ; . Growth Horm IGF Res 13: 295302 Hana V, Silha JV, Justova V, Lacinova Z, Stepan JJ, Murphy LJ 2004 The effects of GH replacement in adult GH-deficient patients: changes in body composition without concomitant changes in the adipokines and insulin resistance. Clin Endocrinol Oxf ; 60: 442 450 Maison P, Griffin S, Nicoue-Beglah M, Haddad N, Balkau B, Chanson P 2004 Impact of growth hormone GH ; treatment on cardiovascular risk factors in GH-deficient adults: a metaanalysis of blinded, randomized, placebo-controlled trials. J Clin Endocrinol Metab 89: 21922199 Hilding A, Hall K, Wivall-Helleryd IL, Saaf M, Melin AL, Thoren M 1999 Serum levels of insulin-like growth factor I in 152 patients with growth hormone deficiency, aged 19 82 years, in relation to those in healthy subjects. J Clin Endocrinol Metab 84: 20132019 and omalizumab.
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Approved in US Canada Capacity GWH 1000 P: 2.6 GPM Maximum output GWH 1000 P: 58 400 Btu hr Maximum input GWH 1000 P: 74 900 Btu hr Efficiency in % Recovery efficiency 78% Min. Output GWH 1000 P: 23 906 Btu hr Gas Requirement Gas connection inches ; - " NPT Inlet gas pressure under maximum operation * Propane: 10.5" - 14" water column Natural Gas: 5.7" - 14" water column. * To measure Gas Pressure, see Measuring Gas Pressure, chapter 3.8. Venting Natural Draft Vent diameter inches ; - 4" Minimum height feet ; - 6' with no elbows Vertical termination. Water Hot water connection inches ; - " NPT Cold water connection inches ; - " NPT Water valve material: Polymer PPS ; Polypropylene Sulfid ; Minimum water flow: 0.5 gallon minute 1.9 l m ; Minimum recommended water pressure: 13 PSI 0.9bar ; Connections: Bottom of heater.
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Table 1. None of the patients had alteration in their regular medications nor other additional antibiotic therapy throughout the baseline period and orphenadrine.
With heart failure. N Engl J Med. 1997; 336: 525533. Pitt B, Segal R, Martinez FA, et al, on behalf of ELITE Study Investigators. Randomized trial of losartan versus captopril in patients over 65 with heart failure Evaluation of Losartan in the Elderly Study, ELITE ; . Lancet. 1997; 349: 747752. Baruch L, Anand I, Cohen IS, Ziesche S, Judd D, Cohn JN, for the Vasodilator Heart Failure Trial V-HeFT ; Study Group. Augmented short- and long-term hemodynamic and hormonal effects of an angiotensin receptor blocker added to angiotensin-converting enzyme inhibitor therapy in patients with heart failure. Circulation. 1999; 99: 2658-2664. Pitt B, Chang P, Grossman W, Dunlay M, Timmermans PB. Rationale, background, and design of the Randomized Angiotensin Receptor AntagonistAngiotensin-Converting Enzyme Inhibitor Study RAAS ; . J Cardiol. 1996; 78: 1129-1131. McKelvie R, Yusuf S, Pericaf D, Held P. Comparison of candesartan, enalapril, and their combination in congestive heart failure: Randomized Evaluation of Strategies for Left Ventricular Dysfunction RESOLVD pilot study ; [abstract]. Eur Heart J. 1998; 19: 188A. Poole-Wilson P, Pitt B. ELITE II Evaluation of Losartan in the Elderly ; Study: the Losartan Heart Failure Survival Study. Paper presented at: 1999 Scientific Sessions of the American Heart Association; November 7-10, 1999; Atlanta, Ga. Cohn J, Archibald DG, Xiesche S, et al. Effect of vasodilator therapy on mortality in chronic congestive heart failure: results of a Veterans Administration Cooperative Study. N Engl J Med. 1986; 314: 1547-1552. Packer M, O'Conner CM, Ghali JK, et al, for the Prospective Randomized Amlodipine Survival and nutropin
I, the undersigned declare that I will participate in the above-mentioned study. I expect to recruit patients per year. I have read the protocol and agree that it contains all necessary details for carrying out the study as described. I will conduct this protocol and any subsequent amendments as outlined therein and will make a reasonable effort to complete the study within the time designated. I will provide copies of the protocol and access to all relevant information I receive to study personnel under my supervision. I will discuss this material with them to ensure that they are fully informed about the study and treatment. I understand that the EORTC may terminate the study or suspend enrollment at any time if it becomes necessary to protect the best interests of the study subjects. I accept the following terms and conditions: 1. As the meetings, correspondence or discussions referred to above may involve matters for which I will be taken into confidence, I will regard as secret and confidential any such information which I may thereby acquire in respect of the manufacturing or commercial interests of the industrial partner, if any and its research. Accordingly I will not disclose such information to a third party. 2. All the trial related minutes of meetings, correspondence or records of discussion together with all other trial documents obtained from the EORTC, other Collaborative groups and or the industrial partners if any ; are confidential and remain the property of the respective partner. This information will be returned to them if requested and orudis.
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7.2.3.3. Time periodic partial measurement case. -- In this part, we consider that m p n and assume that we have at our disposal a periodic gain L t ; such that the time periodic system A t ; - L asymptotically stable. As will appear in the proof in Section 7.5, this assumption is valid provided H 1 and H 2 hold. This means that we have already solved the real-time estimation of x from y measurements when w 0. We propose here an observer design, based on perturbation theory. + For k Ih , denote by Wk t ; , matrix with complex entries, solution of Wk t ; eik0 t A0 t ; 7.9 and oxacillin.
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