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35. Mertens HJ, Heineman MJ, Theunissen PH, de Jong FH, Evers JL. Androgen, estrogen and progesterone receptor expression in the human uterus during the menstrual cycle. Eur J Obstet Gynecol Reprod Biol 98: 58 65, Mowa CN, Iwanaga T. Developmental changes of the oestrogen receptor-alpha and -beta mRNAs in the female reproductive organ of the rat--an analysis by in situ hybridization. J Endocrinol 167: 363369, 2000. Muechler EK, Cary D. Further characterization of estrogen receptors in the human oviduct. Fertil Steril 39: 819 823, Musgrove EA, Lee CS, Cornish AL, Swarbrick A, Sutherland RL. Antiprogestin inhibition of cell cycle progression in T-47D breast cancer cells is accompanied by induction of the cyclin-dependent kinase inhibitor p21. Mol Endocrinol 11: 54 66, Nantermet PV, Masarachia P, Gentile MA, Pennypacker B, Xu J, Holder D, Gerhold D, Towler D, Schmidt A, Kimmel DB, Freedman LP, Harada S, Ray WJ. Androgenic induction of growth and differentiation in the rodent uterus involves the modulation of estrogen-regulated genetic pathways. Endocrinology 146: 564 578, Nishida T, Yasuda H. PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor and repress androgen receptor-dependent transcription. J Biol Chem 277: 41311 41317, Okada A, Ohta Y, Inoue S, Hiroi H, Muramatsu M, Iguchi T. Expression of estrogen, progesterone and androgen receptors in the oviduct of developing, cycling and pre-implantation rats. J Mol Endocrinol 30: 301315, 2003. Okada A, Sato T, Ohta Y, Iguchi T. Sex steroid hormone receptors in the developing female reproductive tract of laboratory rodents. J Toxicol Sci 30: 75 89, Panet-Raymond V, Gottlieb B, Beitel LK, Pinsky L, Trifiro MA. Interactions between androgen and estrogen receptors and the effects on their transactivational properties. Mol Cell Endocrinol 167: 139 150, Pelletier G, Labrie C, Labrie F. Localization of oestrogen receptor alpha, oestrogen receptor beta and androgen receptors in the rat reproductive organs. J Endocrinol 165: 359 370, Pelletier G, Luu-The V, Li S, Labrie F. Localization and estrogenic regulation of androgen receptor mRNA expression in the mouse uterus and vagina. J Endocrinol 180: 77 85, Poukka H, Karvonen U, Janne OA, Palvimo JJ. Covalent modification of the androgen receptor by small ubiquitin-like modifier 1 SUMO-1 ; . Proc Natl Acad Sci USA 97: 1414514150, 2000. Roy AK, Lavrovsky Y, Song CS, Chen S, Jung MH, Velu NK, Bi BY, Chatterjee B. Regulation of androgen action. Vitam Horm 55: 309 352, Sahlin L, Norstedt G, Eriksson H. Androgen regulation of the insulinlike growth factor-I and the estrogen receptor in rat uterus and liver. J Steroid Biochem Mol Biol 51: 57 66, Sakamoto KM, Kim KB, Verma R, Ransick A, Stein B, Crews CM, Deshaies RJ. Development of Protacs to target cancer-promoting proteins for ubiquitination and degradation. Mol Cell Proteomics 2: 1350 1358, Savu L, Benassayag C, Vallette G, Nunez EA. Ligand properties of diethylstilbestrol: studies with purified native and fatty acid-free rat alpha 1-fetoprotein and albumin. Steroids 34: 737748, 1979. Segaloff DL, Ascoli M. The lutropin choriogonadotropin receptor . years later. Endocr Rev 14: 324 347, Shao R, Markstrom E, Friberg PA, Johansson M, Billig H. Expression of progesterone receptor PR ; A and B isoforms in mouse granulosa cells: stage-dependent PR-mediated regulation of apoptosis and cell proliferation. Biol Reprod 68: 914 921, Shao R, Rung E, Weijdegard B, Billig H. Induction of apoptosis increases SUMO-1 protein expression and conjugation in mouse periovulatory granulosa cells in vitro. Mol Reprod Dev 73: 50 60, Shao R, Weijdegard B, Ljungstrom K, Friberg A, Zhu C, Wang X, Zhu Y, Fernandez-Rodriguez J, Egecioglu E, Rung E, Billig H. Nuclear progesterone receptor A and B isoforms in mouse fallopian tube and uterus: implications for expression, regulation, and cellular function. J Physiol Endocrinol Metab 291: E59 E72, 2006. 55. Shao R, Zhang FP, Rung E, Palvimo JJ, Huhtaniemi I, Billig H. Inhibition of small ubiquitin-related modifier-1 expression by luteinizing.

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Fig. 8. a ; Gradient PAGE of beef lung preparation HS-6 subfractions A-C obtained by affinity chromatography on spermine-HiTrap Figure 6c ; and the C-subfractions I-I1I obtained by subsequent gel permeation chromatography results not shown ; . Lane 1, fraction A; lane 2, fraction B; lane 3, fraction C; lane 4, fraction C-I; lane 5, fraction C-II; lane 6, fraction C-III; lane 7, the entire HS-6 pool. The average molecular mass of HS-6 can be estimated to centre around 15, 000-20, 000 Da. b ; Gradient PAGE of pig skin preparation HS-6 subfractions B and D obtained by affinity chromatography on spermine HiTrap Figure 6d ; . Lane 1, B; lane 2; D. For further details, see legend to Figure 7. Effective in most patients. Selected NSAIDs, hydroxychloroquine, sulfasalazine, and azathioprine may be considered for severe or lifethreatening disease. There are also anecdotal reports of intravenous gamma globulin use82 and plasmapheresis99 in pregnant patients with refractory antiphospholipid antibody syndrome or thrombocytopenia. When managing rheumatic disease in pregnant women, one must individualize therapy by carefully assessing and reassessing disease activity and severity, and by recognizing the risk to the fetus. Accepted for publication June 29, 1999. Reprints: Namieta M. Janssen, MD, Section of Rheumatology, B544E, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030 email: janssen bcm.tmc. Were the experimental animal. Before each set of measurements, the air temperature one inch in front of the right and left eyes was measured as well as the humidity and rectal and inferior conjunctival sac temperatures with the use of 0.5 per cent proparacaine hydrochloride Ophthetic ; 0 as the local anesthetic. General anesthesia was then induced with an intravenous dose of 25 mg. per kilogram body weight of pentobarbital sodium Nembutal ; . t For opening and closing the lids, 4-0 catgut sutures were placed in the skin of the upper and lower lids near the lid margin. Rectal and inferior conjunctival sac temperatures were again measured. Most of the ocular temperature measurements were made with the rabbit's head in the erect or vertical position visual axis parallel to the ground ; while the others were made with the rabbit's head in the horizontal position visual axis perpendicular to the ground ; . For each temperature measurement, the thermistor probe was placed in the respective tissue until a constant temperature was noted on the recorder. In order to measure anterior or posterior chamber temperatures, a small superficial incision was made at the limbus with the tip of a keratome in the superior temporal quadrant with the superior rectus muscle for fixation. The incision was then completed by penetration of the needle thermistor, so that the anterior chamber was not lost when the needle thermistor entered the eye. The needle thermistor was then positioned in the pupillary area of the anterior chamber or in the inferior nasal quadrant midway between the pupillary border and the recess of the angle in the posterior chamber, and recording started immediately. The lids were then closed by grasping the sutures, and were maintained closed until a constant temperature was again noted on the recorder. The lids were then opened and kept open until the temperature again became constant. All anterior chamber measurements were determined initially except one where the posterior chamber temperature was determined first. Five of the twelve posterior chamber temperatures were determined initially while the others were taken subsequent to an anterior chamber measurement. Care was taken to insure that the nictitating membrane was retracted and not overlying the cornea when measurements were made with the lids open. The pupil size averaged 6 to 7 mm. throughout all the measurements under general anesthesia. All studies were done during the winter months in the late afternoon. For statistical analysis, the student t test of significance was used in comparing the difference of two means.

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Concerning the liabilities to banks, eur 144 thousand 2005: eur 2, 359 thousand ; are secured by a lien on the property. The long-term liabilities towards banks amounting to eur 20, 000 thousand were to be restructured according to their maturity in short-term liabilities towards banks. Moreover, they were reduced by amortization. The short-term liabilities towards banks reduced despite the effected reclassification out of the longterm liabilities mainly due to amortizations, but also through changes in the group of consolidated companies. The short-term tax liabilities of the previous year concerned almost exclusively taxes on the income of Dyckerhoff ag. The liabilities towards affiliated companies, towards associated. The following table summarized ommended allocations of funds and neomycin.

At each antero-posterior site using a blunt tip needle with two side-holes [16]. After completion of injections the surgical site was washed, the burrhole sealed with bone wax, and the fascia, muscle and skin were sutured in planes. The animal received cephazolin 20 mg kg 12 h i.m. ; and dexamethasone 1mg day i.m. ; for 5 days and analgesia buprenorphine 0.005mg kg 12 h i.m. ; for 3 days. No cyclosporine was given. The animal showed no complications. Motor scores and tests were performed biweekly. Seven months after the transplant the animal was sedated with ketamine 15mg kg ; and terminally anesthetized with Nembutal 25 mg kg, i.v. ; and perfused transcardially with Easy-to-use workflow, sophisticated instrumentation and advanced software to provide rapid and reliable results. The hallmark of the Phoenix System is flexibility. The system can simultaneously perform from 1 to 100 ID AST determinations in three formats: ID only, AST only, or ID AST combined. Additional features are random on-demand loading, single or batch inoculation and continuous monitoring. Furthermore, there are no reagent additions or awkward data entry. And the Phoenix instrument's efficient design reduces maintenance, saves tech hours and minimizes downtime. FDA clearance includes the Phoenix instrument, software and an initial menu of antimicrobial agents for in vitro diagnostic testing. For more information on the BD Phoenix Automated Microbiology System, contact your local BD sales consultant and neoral. This means that while marilyn was alive and mobile, throughout the day, the process of metabolizing the nembutal she had taken had reached the liver and was beginning the process of excretion. The diagnostic criteria of impaired antibody response. There are no universal criteria for adequate antibody response to polysaccharides and each laboratory should establish its own [2]. This is particularly important because of the therapeutic implications. Treatment of symptomatic patients with a lack of antibody response is performed with periodic administration of intravenous immunoglobulins Ig ; at a high cost, dependent on healthcare centres and potential side-effects [3]. For this reason, strict diagnostic criteria must be established. It is interesting to note that VAN KESSEL et al. [1] used different criteria for the response with total antibodies to the serotypes 3, 4 and 9V, in which the post-vaccination titre should be .20 U?mL-1 with at least a two-fold increase for two of the three serotypes, and to the isotypes IgA and IgG2 of the six serotypes studied, in which response was defined individually for each serotype as post-immunisation concentrations .50 U?mL-1 and an isotype responder had to have a positive IgA and or IgG2 response to more than four out of six of the serotypes. The reason for these criteria are not clear and should be based on the knowledge of the response of healthy individuals. With their criteria, a patient could potentially be classified as a reponder if he she presented post-immunisation concentrations of IgA .50 U?mL-1 to five of the six serotypes, but with low concentrations of IgG2 to all serotypes. The clinical meaning of the antibody response with the different isotypes is not equivalent. As an example, the clinical manifestations of patients with IgA deficiency in the form of respiratory infections are due, in great part, to the possible association of an IgG-subclass deficiency, particularly IgG2 deficiency [4, 5]. The usefulness of their response criteria can be validated, at least in part, with the clinical characteristics of the responder and nonresponder patients. There were very few, nonsignificant and probably not clinically meaningful differences between the group of responders and nonresponders. Only the number of resected segments was significantly different in both groups, but it would be interesting to see the number of patients requiring surgery in both groups. This result could be subjected to possible bias in a case in which a single severe patient requiring extensive surgery was included in the group of nonresponders [1]. The next query refers to the meaning of the lack of response to individual serotypes of S. pneumoniae. The immunological interest is clear, but the clinical meaning is controversial. It would be very informative to know the clinical characteristics of the four patients classified as nonresponders by showing post-vaccination total antibody titres below the threshold and comparing them with the remaining 22 patients [1]. In contrast, the lack of response with a particular isotype of Ig to one or some individual serotypes can potentially be less harmful than the lack of response with total IgG or IgG2 to all serotypes considered together. This last condition may be a marker of a more profound impairment in antibody response and, if this impairment is also observed against conjugated polysaccharides such as the Haemophilus influenzae type B Hib ; vaccine in a patient with recurrent respiratory infections, it is a criterion for Ig replacement therapy [6]. This lack of response to both vaccines is a characteristic of patients with a severe immune impairment [6]; however, it is not at all clear that the lack of and nesiritide.

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We examined the visual conices of 15 kittens at different developmental stages and of 6 adult cats see Table 1 ; either by in vitro labeling with the carbocyanine dye Dil Godement et al., 1987 ; or by in vivo tracing with rhodamine-labeled latex microspheres Katz et al., 1984 ; in combination with intracellular Lucifer yellow staining Buhl, 1993 ; . These two complementary methods were applied in order to minimize methodological bias. In vitro Tracing tvitb Dil Animals were deeply anaesthetized with a lethal dose of pentobarbital Nembutal ; and then transcardially perfused with phosphatebuffered 4% paraformaldehyde PA ; . Brains were removed and postfixed in 4% PA. Two to 5 d later a single crystal of the carbocyanine dye Dil Molecular Probes, Eugene, OR ; , measuring about 200 jun in diameter, was implanted into the primary visual cortex area 17; Fig. la-cy within the presumed representation of the area centralis Tusa et al., 1978 ; . After incubation times of 6 months to 2 years 70 or 100 u.m thick vibratome sections were prepared from the visual cortex in the horizontal plane. The sections were mounted on slides in 0.1 M phosphate buffer, pH 7.4 PB ; , coverslipped, sealed with nail varnish, and examined with a Zeiss Photomikroskop in equipped with a rhodamine epifluorescence filter set. A few sections were counterstained with cresyl violet or nuclear yellow Schmued et al., 1982 ; to determine the cortical layers and the borders of area 17 according to the criteria of Otsuka and Hassler 1962 ; . In order to obtain permanent preparations of the Dil-labeled cells, a representative sample of the sections was photooxidized in 3, 3'-diaminobenzidine for de. Grouped together. The outcome of this analysis is shown in Table 5. The maximum clearance Cmax ; was 1.39 M, t1 2, was 0.25 hours, t1 2, was 3.67 hours, and area under curve AUC ; 6.02 M hour. The parameter estimates all gave reasonable standard. Overall, the pharmacology observed in this study was similar to those reported in a previous study by Sandor et al, 39 which used comparable doses of depsipeptide and nettle Three new planets orbiting around a star other than our own have been discovered. They orbit around HD69830, 40 light years * away, and have features which appear to be similar to planets in our own solar system: they have a stable configuration, and the innermost planet is rocky, the next is rocky and surrounded by gas, while the outermost one has a gaseous envelope surrounding a rocky, icy core. All treatments were approved and in compliance with the requirements of the animal care and use committee of the University of Pittsburgh or Dartmouth Medical School. Male Sprague-Dawley rats, weighing 175200 g, were purchased from Zivic Miller Zelienople, PA ; , Harlan Sprague-Dawley Indianapolis, IN ; , or Charles River Laboratories Burlington, MA ; . Rats had free access to water and food at all times during the study. Hypothyroidism was induced by the addition of MMI 0.025% or 0.05% ; to the drinking water. Hypothyroidism was assessed clinically by failure to gain weight at the expected rate and could be observed within 2 weeks of beginning MMI treatment. In an initial study, the experimental groups n 6 rats group ; included euthyroid control animals, animals receiving MMI for 4 weeks, and euthyroid animals treated with l-T3 50 g 100 g BW, sc, daily ; for 4 days before death to induce a hyperthyroid state. A second series of experiments was conducted using a longer period of thyroid hormone treatment. Rats taking MMI for 2 weeks were continued on this agent for an additional 2 weeks, during which time they were administered once daily ip injections of l-T4, l-T3, or 10 mm sodium hydroxide vehicle. Rats treated with l-T4 received daily ip doses of 0.1 n 6 ; , 0.2 n 6 ; , 0.5 n 6 ; , 1.5 n 10 ; , 3 4.5 n 5 ; , or 100 g BW n Treatment with l-T3 involved administering doses of 0.25 n 10 ; , 1 1.7 n 4 ; , 3 100 g BW. Sixteen rats receiving MMI, treated only with vehicle, served as hypothyroid controls. Six euthyroid rats served as additional controls. The chosen doses of administered thyroid hormone were based on previous reports suggesting that l-T4 at 510 g 100 g BW day induces thyrotoxicosis 28, 29 ; . Furthermore, T3 nuclear receptor saturation with an accompanying alteration in the transcriptional activity of specific liver genes is induced with l-T3 treatment in a dose of 1550 g day 30 ; or with a single dose of 200 g T3 31 ; Serum T4, serum T3, T3 uptake, and cortical D2 mRNA concentrations were measured at the time of death in all chronically treated animals. Hepatic type I iodothyronine deiodinase D1 ; mRNA and activity and cerebral cortex D2 activity were assayed in selected samples, including euthyroid rats and those receiving MMI receiving vehicle or low dose l-T3 or l-T4 treatment dosage range, 0.13 g 100 g BW ; . The time course of thyroid hormone effects on D2 mRNA and activity was determined using rats rendered hypothyroid by the inclusion of MMI in their drinking water for 50 days. At the end of this period, animals were administered vehicle, 50 g l-T4 n 5 ; , or 200 g l-T3 n 5 ; as a single ip dose 24 h before death. This experiment was repeated in MMI-treated rats who received vehicle or 200 g l-T3 4, 12, or 24 h before death, and results were compared with those from a euthyroid control group n 4 group ; . Serum T4, serum T3, T3 uptake, and cortical D2 mRNA and activity were measured in all animals. Rats were killed in the morning 24 h after the last dose of l-T3 or l-T4, or as otherwise noted ; under Nembutal anesthesia by exsanguination through the carotid arteries. Brains were quickly removed, and the cortex was dissected out on ice for storage at 80 C until RNA extraction or homogenization for activity and neulasta.

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Sedation regimens vary greatly from one institution to another and even among physicians in the same department. There is no consensus on the best protocol for the sedation of children 2 ; . The choice of drugs and route of administration depends on the patient's age, history of underlying illness e.g., mental deficiency, cardiac or respiratory illness ; , experience and familiarity with certain drugs, institutional protocols, length of procedure and availability of support reversal drugs ; . In infants and young children, rectally, or more commonly, orally administered drugs are adequate for sedation. Rectal absorption tends to be erratic and the oral method is usually the preferred route of administration. Chloral hydrate is commonly used in infants and young children usually 10-15 kg ; and is recommended by the AAP as an "effective sedative with a low incidence of acute toxicity when administered orally in the recommended dosage for short-term sedation" 3 ; . Chloral hydrate in a dose of 50-70 mg kg maximum total accumulated dose of 100 mg kg ; is usually adequate to achieve sedation. The maximum total dose varies according to the guidelines of the individual institution 4 ; . Often in older, larger or mentally deficient children chloral hydrate doesn't suffice as the only sedation and additional medication may have to be added to the sedation regimen 5 ; . In older patients and children with mental deficiency, parenteral sedation, usually intravenous, may be the preferred method. Intravenous sedation allows for rapid induction and recovery with better scheduling of sedation cases during high volume periods. However, intravenous sedation must be titrated for each patient using the recommended dosage range. Pentobarbital sodium Nembutal ; is popular because it is a short-acting barbiturate with low incidence of respiratory de pression. It is commonly used in dosages of 2-6 mg kg. The maximum dosage varies according to the guidelines of the. The Pussiette, meanwhile, was quite conscious that the lips on her nipples were female, but that somewhat queer note didn't disturb her; rather, it added to the general excitement. The finger in her honey-box must have been male, and the cock in her mouth definitely was, and she reached out one caressing hand to the breasts of the girl who was sucking on her, while feeling Dr. Prong's prong suddenly get hotter and harder in her mouth, and she suddenly had a flash of thinking group ecstasy reverberating by chain reaction from one to another must be what heaven was like, but then the hot salty spash on her tongue catapulted her into ecstasy and Dill moved his finger carefully inside her to help her along and the other girl nibbled very gently on her nipples and she went completely out of herself in spasm after spasm. And even Dr. Prong had quite forgotten about the sinister machinations of Ezra Pound and the Fair Play for Fernando Poo Committee and neupogen.

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PATIENT POPULATION The meanSD age of our subjects was 59.0 13.5 years range, 28.8-84.2 years ; , including 27 women and 5 men. Within this group, there were 12 Sjogren and 20 non Sjogren patients. LYMPHOCYTIC MARKERS In general, there was a decrease from baseline in the number of cells positive for CD3, CD4, and CD8 following and nexavar. Defendants point out that this evidence shows that there were 21 pills missing. Defendants argue that this number correlates to the seven-day period between Clutters' booking into the Jail, and his visit to Dr. Canos. Defendants argue that this demonstrates that Clutters was given his medication during that period of time. Plaintiff also brings claims of "recklessness, " "denial of medication, " and "denial of medical treatment." Instead of analyzing these as separate claims, the Court construes these claims as being elements of the other claims plead!

By Anna Bradley Dear Editor, I read your 5 18 article about the frantic efforts of local parents to shield their children from the gruesome images on the evening news with a great deal of sadness-and alarm. The experts, it seems, think it's best to "protect" children by keeping them ignorant. Ignorance protects no one. I grew up in the shadow of World War II, and in the blue white glow of the ever-on television set. My family watched TV, and we especially watched the evening news. Every night, over dinner, Walter Cronkite. What I saw then, as a five year old, remains with me to this day. It was the Hungarian revolt of 1956. Guys in street clothes lurking in doorways, with pistols and rifles and Molotov-cocktails taking on Russian tanks. I wasn't frightened, I was thrilled. Wow, who are these really brave people? My dad told me they were Hungarians; he explained why they were fighting the Russians. We had a map pinned to the wall of the kitchen, and I learned a little geography. This is Hungary, this is Budapest--miles and oceans away from me, but also the homeland of several of the families on our street. The images were gruesome. I remember a truck piled high with wounded insurgents flying a makeshift flag- a bedsheet with a Red Cross marked out in the blood of the wounded. I also remember the "good-guy" insurgents lynching a Communist official in a public square. My dad said that, in war, even good people can do terrible things. So, was I traumatized? No, I was educated. I learned some geography, some history, and I learned, deeply and forever, that there is no way that some great power can run tanks into some smaller, weaker country and expect anything but what we have now in Iraq and nicardipine.

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The environment. This is first suggested by Rawls's own line of argument in A Theory of Justice. In Section 33, Rawls argues that parties in the original position would secure liberty of conscience-- the freedom to think one's own thoughts and to further express those thoughts as long as such expression does not directly cause harm to others. Part of the reason for this is that only by securing equal protection of liberty can a conception of justice be justifiable to future generations. He writes, "We can express this by noting that were a father, for example, to assert that he would accept the principle of equal liberty, a son could not object that were he the father ; to do so would be neglecting his the son's ; interests" 4 ; . That is, Rawls argues that his theory ought to be preferred over alternatives because future generations cannot reject it. The applicability of this argument to the environment is clear if focus is shifted from the right to liberty of conscience to the right to a healthy environment. Is such a right justifiable? That is, would parties in the original position rationally agree to such a right? It has already been established that if it is rational for parties to agree to a universal right in the original position, then Rawls's theory demands that justice protect such a right. Therefore, if the right to a healthy environment is rational to agree to in the original position, then justice demands that right be protected. It is clear that Rawls's argument in Section 33 lends support to the conclusion that parties in the original position would agree to such a right. Descendants of those in the original position could not reasonably object to the conception of justice that guaranteed them a healthy environment because it included the right to a healthy environment, whereas they could object to a conception of justice that did not guarantee them such a right. If parties in the original position did guarantee the right to a healthy environment, then the environment would be strongly and neomycin.
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