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Discuss with your doctor the appropriate use of birth control during treatment with idarubicin if necessary.
Ef, left ventricular ejection fraction; fc, functional class; chf, congestive heart failure; dft, defibrillation threshold; m, male; f, female; cad, coronary artery disease; vt, ventricular tachycardia; as, aortic stenosis; dcm, dilated cardiomyopathy; hcm, hypertrophic cardiomyopathy; avr, aortic valve replacement; coa, coarctation of the aorta; cm, cardiomyopathy; vf, ventricular fibrillation; icd, implantable cardioverter-defibrillator; na, not available.

Idarubicin alternative 1. Motherisk Program Hospital for Sick Children, Toronto 9-5 weekdays Information specialist: 41 6 ; -813-6780 OR: Clinical consultation by referral. 2. Safestart Program- McMaster University, Hamilton 905 ; -521-2100 Ext. 6788 Dr. Elizabeth Chow-Tung Leave detailed message-receive call back. Among the drugs used in both types of acute leukemia. Idarubicin IDA ; is a relatively new antitumor anthracycline drug and is thought to be more active and less cardiotoxic than daunorubicin DNR ; [2]. Resistance to anthracyclines may compromise therapy results. The resistance may be caused by reduced intracellular drug levels due to its sequestration by multidrug resistance proteins or detoxification by glutathione and its S-transferases, a reduced amount of active intracellular drug target, such as topoisomerase II, and resistance to apoptosis or its protein disregulation [3]. Anthracyclines enter the cell by passive diffusion, most likely in an unchanged form [4, 5]. So far most information about anthracycline resistance was obtained from in vitro studies on tumor cell lines. There is only one study on childhood acute leukemia, reporting a relationship between intracellular DNR concentration, expression of resistance proteins and DNR cytotoxicity in ALL [6]. It shows that intracellular DNR concentration and the expression of Lung-Resistance-Protein MVP LRP ; , but not P-glycoprotein PGP ; , may contribute to DNR resistance in childhood ALL. So far there are no reports available showing whether intracellular IDA content is related to cellular drug resistance and multi-drug resistance proteins expression in childhood leukemia. Moreover, it is unknown what differences in intracellular anthracycline levels occur between ALL and. Epirubicin Hydrochloride, 50 mg Etoposide, 10 mg Etoposide, 100 mg Floxuridine, 500 mg Fludarabine Phosphate, 50 mg Fluorouracil, 500 mg Fulvestrant, 25 mg Gemtuzumab Ozogamicin, 5 mg Goserelin Acetate Implant, per 3.6 mg Idarubicin Hydrochloride, 5 mg Ifosfamide, 1 gm Interferon, Alfa-2A, Recombinant, 3 million units Interferon, Alfa-2B, Recombinant, 1 million units Interferon, Alfa-N3, Human Leukocyte Derived ; , 250, 000 IU Interferon Beta-1A, 11 mcg for intramuscular use Interferon Beta-1A, 11 mcg for subcutaneous use Interferon, Gamma 1-B, 3 million units Leuprolide Acetate, per 1 mg Leuprolide Acetate for depot suspension ; , 7.5 mg Leuprolide Acetate Implant, 65 mg Lymphocyte Immune Globulin, Antithymocyte Globulin, equine, parenteral, 250 mg Lymphocyte Immune Globulin, Antithymocyte Globulin, rabbit, parenteral, 25 mg Lyophilized Cyclophosphamide, 2.0 gm Mechlorethamine HCL nitrogen mustard ; , 10 mg Melphalan Hydrochloride, 50 mg Mesna, 200 mg Methotrexate Sodium, 5 mg Methotrexate Sodium, 50 mg Mitomycin, 5 mg Mitomycin, 20 mg Mitomycin, 40 mg Mitoxantrone HCL, per 5 mg Muromonab-CD3, parenteral, 5 mg Not otherwise classified, antineoplastic drugs. Idarubicin dosage

Idarubicin chemotherapy Anthracyclines are among the most active agents in the treatment of breast cancer both in the metastatic and adjuvant settings [1, 2]. Doxorubicin and epirubicin are associated with commonly reported side effects such as alopecia, vomiting, mucosal toxicities, extravasation reactions and the particularly feared cardiomyopathy. Idarubicin IDA ; , a synthetic analogue of daunorubicin, differs from the parent compound by an increased lipophilicity and a better oral bioavailability [3, 4]. It is an active drug in both metastatic breast cancer and leukaemia [58] and appears to be less cardiotoxic than doxorubicin, particularly attractive for elderly patients [9]. We conducted a phase I study of oral IDA in patients with metastatic breast cancer no age limits ; pretreated with anthracycline-containing regimens [10] to evaluate the chronic and ifex. The study published in the May 27 issue of The Journal of the American Medical Association showed that those who had taken the statin had 37 percent fewer heart attacks and other serious signs of heart disease than those who received a placebo. The authors of the study said that, if the study's findings were implemented, the population eligible for statin therapy would quadruple to 8 million Americans. A lead author of the study, Dr. Antonio M. Gotto Jr., Dean of the Weill Medical College of Cornell University, said that previously physicians did not prescribe statins to patients with average cholesterol levels because they "thought it probably wouldn't do any good." He said the study showed that this was not true. A similar study, reported in the November 5 issue of The New England Journal of Medicine, found that anticholesterol drugs can significantly reduce the risk of death in heart-attack victims, even if their cholesterol levels are not greatly elevated. The study of more than 9, 000 people showed that a cholesterol-lowering drug reduced deaths from heart disease by 24 percent over a six-year period. FIRST GAZETTE NOTICES -CONTINUED. PEAKBASE DEVELOPMENTS LIMITED PEAKLINK LIMITED PEARL ENTERTAINMENT LIMITED PEARLS LEISURE LIMITED PEARL WALTER LIMITED PEBBLE MARKETING LIMITED PEDAL LTD P.E.F.F.I.X. LIMITED PEGASUS AVIATION NORTH WEST ; LIMITED PEGASUS HEATING AND PLUMBING LIMITED PELATON SOLUTIONS LIMITED PELFACO LIMITED PELICULA LIMITED PELLAGRIN LIMITED PELLARO LIMITED PENANG LIMITED PENDLE PLUMBING & HEATING MERCHANTS LTD PENFOLD FARMS LIMITED THE PENNY PUB COMPANY LIMITED PENSKI SERVICES LTD PENTHER KAMINVERTRIEB LIMITED PENYARDS PRIVATE FINANCE LTD PENYARDS PRIVATE INVESTMENT LTD THE PEOPLE CHANNEL PEOPLE`S BROADBAND COMMUNICATIONS LIMITED PEPLOW & THOMAS INSURANCE CONSULTANTS ; LTD. PERAK LIMITED PERCHANCE TRADING LIMITED PERENNIAL PROVERBS & SAYINGS INT ; LTD PERENNIAL STAFFING LIMITED PERFECT FASHION LIMITED PERFECT FRIED LTD PERFECTION LIMITED PERFECT IT LIMITED PERFORMANCEBITZ LIMITED PERFUMES AND COSMETICS DISTRIBUTORS LIMITED PERMATECH EUROPE LIMITED PERRIMOOR ASSOCIATES LIMITED PERRYLANDS FARM LIMITED PERSIAN PUSSYCATS LTD PERUZZI SERVICE PROVIDERS LIMITED PETALING LIMITED PETALS WEDDING & FLORAL DESIGNS LTD PETER CHARLESTON LTD PETER CLARE LTD PETERPIX PRODUCTIONS LTD PETE`S TAKEAWAY LIMITED PETIL LIMITED PETROU TECHNOLOGY LIMITED PETRUSOIL UK LIMITED PET-TASTIC LIMITED PETTINEO LIMITED PG FINANCIAL TRAINING LIMITED 03610500 05327763 03256493 PGI ENERGY LTD PGR COMPUTING LIMITED P HARDY SERVICES LIMITED PHARMA ALLIANCE INTERNATIONAL LIMITED PHARMACEUTICAL COMPUTER SYSTEMS LIMITED PHARMANATURE LTD PHEONIX INT LIMITED P. H. HOLDINGS LIMITED PHIL BOWERS LIMITED PHIL DAWES PLUMBING & HEATING LIMITED PHILLIP & EUGENIA LTD PHIL ROBERTS MEDIA LTD PHIRO SERVICES LTD PHLY LIMITED PHOENIX AUTO CORPORATION 99 LIMITED PHOENIX HOSPITALS LIMITED PHOENIX MANUFACTURING LIMITED PHOENIX SECURITIES CITY ; LIMITED PHOSPHATE TECHNOLOGY CONSULTANTS LTD. PIANA LIMITED PICCADILLY TANNING CENTRE LIMITED PICK AND PLACE TECHNOLOGY LIMITED PICLON SERVICES LIMITED PIEDRA COMPUTING LIMITED PIERTEX UK LIMITED PIMAC SERVICES LIMITED PIMCO 2283 LIMITED PINEWOOD SPORTING LTD PINK PIRANHA RETAIL ; LIMITED PINNACLE CONSTRUCTION MANAGEMENT & COST CONSULTANTS LIMITED PINNACLE FACILITIES & PREMISES MANAGEMENT LTD PIRITRO VENTURES LIMITED PIR NA NOG DISTRIBUTIONS LIMITED PIRTEK PRESTON ; LIMITED PISEAF 320 LIMITED PITCHDREAM LIMITED PI TECHNICAL SERVICES LIMITED PITMAN TRAINING UK LIMITED PIXELMANIA LIMITED PIZZA DELIGHT LIMITED PIZZA JUNCTION LIMITED P J ARMITAGE LIMITED P JAYS FLORAL DESIGNS LIMITED P.J.C. ELECTRICAL SERVICES LIMITED PJE UTILITIES LIMITED PJR ENTERPRISES LIMITED PJ'S COMMUNITY SERVICES LIMITED PKR PLUMBING AND HEATING SPECIALISTS LTD PLAFED SOLUTIONS LIMITED PLAN B BARS LIMITED PLAN C LIMITED PLANET FISHING & SAFARIS LTD. PLANET MAIL LIMITED 04407931 02225769 05256776 and ifosfamide. Idarubicin dosing

Determine significant differences in osa values between the three ethnic groups, and spearman's correlation coefficient rs ; to detect associations between osa and craniofacial variables.
Patient Samples. Patient-derived cell samples n 45; bone marrow n 35, peripheral blood n 10 ; were consecutively collected, ficoll-purified, and cryopreserved between 1997 and 1999 within the German multicenter AML-BFM93 study. Diagnosis of AML was made morphologically based on FAB criteria 24, 25 ; and immunophenotypically according to European Group for the Immunological Characterization of Leukemias EGIL ; recommendations 26 ; . All of the samples contained more than 80% leukemic cells based on morphological and immunophenotypical criteria. All of the patients were children and had de novo AML. Clinical characteristics of these patients are summarized in Table 1. Treatment According to German AML-BFM93 Study Protocol. Treatment modalities and risk stratification of the AML-BFM93 study are described in detail elsewhere 18 ; . In brief, during induction phase, patients received either ADE ara-C: 100 mg m2, day 1 to 8; daunorubicin 30 mg m2 twice daily, days 3 to 5; etoposide 150 mg m2, day 6 to 8 ; AIE idarubicin 12 mg m2 daily instead of daunorubicin ; . Although AIE was associated with a better blast reduction in the bone marrow on day 15, long-term therapy outcome for both induction regimens was similar 27 ; . After induction, patients were treated according to risk level standard-risk group: FAB M1 or M2 with Auer rods, FAB M3, and FAB M4Eo with 5% blasts in the bone marrow on day 15; high-risk group: all others ; . Standard-risk patients were shifted to the high-risk group if they had more than 5% blasts in the bone marrow on day 15. Patients with FAB M3 were always treated within standard-risk group, regardless of blast count on day 15. All of the patients received 6 weeks of standard consolidation therapy with seven drugs thioguanine 60 mg m2, day 1 to 43; prednisolone 40 mg m2, day 1 to 28; vincristine 1.5 mg m2 and doxorubicin 30 mg m2, day 1, 8, 15, an 22; ara-C 75 mg m2 day 3 to 6, 10 13, to 20, 24 to 27, 31 to 34, and 38 to 41; intrathecal ara-C 40 mg in children 3 years, day 1, 15, 29, and 43; cyclophosphamide 500 mg m2 day 29 and 43 ; . High-risk patients were randomized to receive additional consolidation treatment with HAM highdose ara-C 3 g m2 twice daily, days 13; mitoxantrone 10 and iloprost.
There is no conclusive information about idarubicin adversely affecting human fertility or causing teratogenesis. There has been one report of a fetal fatality after maternal exposure to idarubicin during the second trimester. There are no adequate and well-controlled studies in pregnant women. If IDAMYCIN is to be used during pregnancy, or if the patient becomes pregnant during therapy, the patient should be apprised of the potential hazard to the fetus. Women of childbearing potential should be advised to avoid pregnancy. PRECAUTIONS.

Table 3. Percentage of multilineage differentiation in NOD-SCID mice of human CD34 cells transduced in the presence of ABC transporter inhibitors. 1. Tuulonen A, Airaksinen PJ. Funduscopic and photographic characteristics of the retinal nerve fiber layer in glaucoma. In: Podos SM, Yanoff M, Kaufman PL, Thomas W, eds. Textbook of Ophthalmology. Glaucoma: Philadelphia, Pa: Mosby Year Book Inc; 1994: 4.12-4.19. 2. Schuman JS, Hee MR, Pulifiato CA, et al. Quantification of nerve fiber layer thickness in normal and glaucomatous eyes using optical coherence tomography: a pilot study. Arch Ophthalmol. 1995; 113: 586-596. Burk ROW, Rohrschneider K, Takamoto T, Volc ker HE, Schwartz B. Laser scanning tomography and stereophotogrammetry in threedimensional optic disc analysis. Graefes Arch Clin Exp Ophthalmol. 1993; 231: 193-198. Tuulonen A, Airaksinen PJ. Optic disc size in exfoliative, primary open angle, and low-tension glaucoma. Arch Ophthalmol. 1992; 110: 211-213 Chihara E, Chihara K. Apparent cleavage of the retinal nerve fiber layer in asymptomatic eyes with high myopia. Graefes Arch Clin Exp Ophthalmol. 1992; 230: 416-420 and iressa.

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