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The purpose of Cronos' foreign currency hedging activities is to reduce the risk that sales transactions that are denominated in non US dollar currencies will be aected by adverse exchange rate movements between the US dollar and the sales transaction currency. During 2003, Cronos entered into foreign currency forward contracts to reduce exposure to exchange rate risks associated with a Euro denominated sales agreement. Each forward contract was designated a fully eective cash ow hedge as the critical terms of each contract matched those of the hedged item. The changes in the fair value of the hedges were reported as a component of other comprehensive income and were reclassied into earnings as equipment trading revenue on the contracted performance dates of the sales agreement. The estimate of fair value was based on the estimated replacement cost of each hedge. The nal forward contract expired in June 2004. For the year ended December 31, 2004, 5 was reclassied from other comprehensive income to equipment trading revenue on the contracted sales agreement performance dates. 12 Other assets Other assets include the following items.
The BEST Foundation turned once again to the RAND Corporation in Santa Monica, CA whose research scientists helped develop the original Project ALERT curriculum in 1984 and have assisted with content revisions since then. Working together, Phyllis Ellickson, Katherine Watkins, Mary Vaiana, and Scott Hiromoto researched and gathered information, then convened a panel of experts in medicine, toxicology, adolescence, drug prevention and treatment, substance abuse, psychiatry, and law enforcement to study the problem and help develop the best approaches to prevention and education. Prevention messages on the fact sheets are reinforced with quotes gathered from several teen focus groups, plus teen magazines and websites. Information from the focus groups revealed that marijuana still dominates illegal drug use among teens, and that most teens know little factual information about over-the-counter and prescription medications. They hear about steroid use among athletes, but don't know the long term effects of steroids on the body. "Kids think prescription drugs are okay because doctors prescribe them, " said Katherine Watkins. "But, as just one example, one dose of OxyContin, which is a powerful painkiller, can be fatal if used incorrectly. We felt that information was so important that we've added a question about it in the new Q&A." In writing the new materials, RAND staff found it challenging to select language they felt was accessible to both students and
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P111 HEALTH-RELATED QUALITY OF LIFE EFFECTS OF PEGYLATED INTERFERON-ALPHA AND RIBAVIRIN THERAPY IN HCV MONOINFECTION AND HIV-HCV COINFECTION Thein H-H1, Maruff P2, Krahn M3, Kaldor J M1, Koorey D4, Brew B J1, 5, 6, Dore G J1, 6 1 National Centre in HIV Epidemiology and Clinical Research, The University of New South Wales, Sydney, NSW, Australia; 2La Trobe University, Melbourne, Australia; 3 Departments of Medicine and Health Policy, Management and Evaluation, University of Toronto, Ontario, Canada; 4 Gastroenterology and Hepatology Unit, Royal Prince Alfred Hospital, Sydney, NSW, Australia; 5Department of Neurology, St. Vincent's Hospital, Sydney, NSW, Australia; 6 HIV Immunology Infectious Diseases Clinical Services Unit, St. Vincent's Hospital, Sydney, NSW, Australia Health-related quality of life HRQOL ; in HIV-HCV coinfected individuals with no previous HCV treatment appears similar to HCV monoinfected individuals. The aim of this study was to examine the HRQOL effects of pegylated IFN-alpha and ribavirin therapy in both clinical groups. Participants recruited from two tertiary level hepatitis clinics in Sydney completed a self-administered questionnaire seeking information about perceived hepatitis C-specific symptoms prior to pegylated IFN-alpha and ribavirin combination therapy, at weeks 18 and 42 on-treatment, and 24 weeks following completion of treatment. HRQOL was assessed using the Short Form-36 Health Survey SF-36 ; , Visual Analogue Scale VAS ; and SF-6D. Between and within groups comparisons were performed using Student's t test and ANCOVA controlling for age. The HIV-HCV coinfected group n 15 ; was significantly younger 36 vs. 43 years, p 0.004 ; than the HCV monoinfected group n 19 ; . Both HCV monoinfected groups showed moderate to large decrements in HRQOL scores from pre-treatment to week 18 on-treatment HCV: physical component summary PCS ; : 47.4 to 40.6, p 0.09, effect size d -0.72 mental component summary MCS ; : 41.9 to 36.4, p 0.1, d -0.64; HIV-HCV coinfected: PCS: 47.5 to 39.4, p 0.06, d -0.84; MCS: 39.6 to 33.6, p 0.2, d -0.57 ; . This decrement persisted through week 42 ontreatment among the HIV-HCV coinfected group. Moderate to large gains in HRQOL scores from pre- to post-treatment were also observed in both groups HCV: PCS: 47.2 to 51.2, p 0.3, d -0.50; MCS: 42.6 to 50.7, p 0.03, d 1.07; HIVHCV: PCS: 46.9 to 52.4, p 0.2, d 0.60; MCS: 42.1 to 52.5, p 0.03, d 1.25 ; . There were no significant differences in HRQOL between the two groups in all measures at each time point. Among individuals who completed followup n 25 ; , 64% achieved a sustained virological response. There were no significant differences in pre- PCS: 47.1 vs. 47.3, p 0.9, d 0.02; MCS: 43.4 vs.39.7, p 0.3, d -0.44 ; and post-treatment PCS: 52.5 vs. 45.1, p 0.08, d -0.79; MCS: 51.4 vs. 50.5, p 0.8, d -0.12 ; HRQOL scores between sustained virological responders SVR ; and non-responders. However, post-treatment PCS score was marginally higher in the SVR. Our results suggest that there is no evidence of greater HRQOL impairment in HIV-HCV coinfected than HCV monoinfected individuals at all phases of pegylated IFNalpha and ribavirin therapy. Larger prospective studies may be able to more rigorously evaluate differential impact of treatment across HCV patient groups. P112 SUBSTITUTION TO EFAVIRENZ FOR NEVIRAPINE ASSOCIATED ELEVATIONS IN LIVER FUNCTION TESTS: A RETROSPECTIVE MULTI-CENTRE CASE NOTE REVIEW Vlahakis E1, Doong N2, Anderson J3, Batterham M4, Pell C1, 5, Bodsworth N1 1 Taylor Square Private Clinic, Sydney, NSW, Australia; 2Burwood, NSW, Australia; 3The Carlton Clinic, VIC, Australia; 4University of Wollongong, NSW, Australia, 5 Sydney Sexual Health Centre, NSW, Australia Elevations in liver function tests LFT's ; can occur in up to 10% of patients taking nevirapine treatment for HIV infection. These elevations can result in clinical hepatitis in some cases and may persist. We performed a retrospective analysis on 23 patients who had elevated LFT's whilst on nevirapine and who had efavirenz substituted for nevirapine. Significant improvements in ALT and bilirubin were noted after 12 weeks with a trend to reduction in ALT and GGT. All patients who had an undetectable HIV viral load at the time of switch remained undetectable. CLINICAL MEDICINE POSTER ABSTRACTS.
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Figure 2.4: Graphical representation of the edge-hinge joint probability distribution. One half of the 3D plot situated on one side of the main diagonal ; is flat because we only consider the angle combinations with 2 1 and emend.
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Alright, we discused the first several options, and the others you'll recall from the VxMake course when you made striped plexes. "layout" specifies the layout type for the volume we're building concat, stripe, mirror, RAID5, etc ; . The options "stwidth" and "ncolumn" are stripe specific options defining the width of the stripe unit for each column. The remaining options specify the vmdisks we want vxassist to use in building this volumes. It should be noted that we can use as many or as few of these options as we like. For instance, we can make the layout "stripe" but not specify the stripe width or number of columns. We can specify the stripe width and stripe layout, but not the number of columns or disks to use. You should exersies some common sense when omiting options, thinking of what vxassist is going to need to be told to make it's choice, but without being told it will do the best it can to meet your request. In the following examples we'll build a striped volume using only the "layout" option, and letting vxassist figure the rest out
6. Did you perceive commercial bias defined as the obvious appearance of skewed material which has been influenced by commercial support ; in the contents of the material presented in this CME activity? If yes, please explain below. Commerical Bias comments and or suggestions for improvement and emtriva.
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For which details of are presented at section 3. These tariffs have been calculated taking advice from the Audiology Advisory Board. The tariff is component-based and calculated using a combination of DH reference costs data and cost data from the NHS Purchasing and Supply Agency. Reference costs data has been used to calculate the tariff prices for assessment, fitting and follow-up assessment whilst cost data from the NHS Purchasing and Supply Agency has been used to calculate the tariff price for the devices a weighted average price including both digital and analogue devices.
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12. Research and Development Costs: Research and development costs included in selling, general and administrative expenses for the years ended March, 2005 and 2004 amounted to 6, 271million , 607 thousand ; , 6, 360million, respectively and enfuvirtide.
Vaccine Recent changes in the NIP Prevenar is the only licensed pneumococcal conjugate vaccine PCV ; for protection of infants and children up to five years of age in Europe. This 7-valent PCV, also designated as PCV7, provides protection against invasive disease caused by the 7 most prevalent serotypes in the USA.57 In the Netherlands around 68% of cases of pneumococcal meningitis among children less than two years of age is caused by PCV7 serotypes see Figure 6 ; . Vaccination with Prevenar has been introduced in the Dutch NIP in April 2006. PCV7 is given to infants at two, three, four and eleven months of age at the same time as the DTaP-IPV Hib combination vaccine albeit as a second injection in a different limb of the child.
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The motion was amended as follows: that ONB recommends the doubling of event registration fees for nonmembers except for wayfarers on course one and two. Motion #11 by Ray St. Laurent to post AGM agenda items prior to meeting. This is to avoid brainstorming during meeting and motions being raised during the meeting. Motion #12 was #3 ; by Don Heron Dave Ross for ONB to and enoxaparin.
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The certification set forth below is being submitted in connection with the Annual Report of the Company on Form 10-K for the year to December 31, 2004 the Report ; for the purpose of complying with Rule 13a-14 b ; or Rule 15d14 b ; of the Securities Exchange Act of 1934 the "Exchange Act" ; and Section 1350 of Chapter 63 of Title 18 of the United States Code. Matthew Emmens, the Chief Executive Officer and Angus Russell, the Chief Financial Officer of Shire Pharmaceuticals Group plc the Company ; , each certifies that, to the best of his knowledge: 1. the Report fully complies with the requirements of Section 13 a ; or the Exchange Act; and 2. the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company and entacapone.
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