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Inhibition of Vial Synthesis with an ll-Desoxy C-21 Steroid Desoxyhydrocortisone ; .--A wide variety of C-21 steroids other than cortisone are effective.
Readily absorbed and distributed through the body tissues; elimination half-time 3-11 hrs. Headache, gastrointestinal disturbances, hypotension, irritability, arrhythmia, seizures and death; No association with benign breast disease or breast cancer; No association with congenital abnormalities or stillbirth were seen in studies with females receiving theophylline. Theophylline had no effects on the development of premature infants.

Female rats, ranging in ages from 3 to 4 months and weighing 200"260 gm., were used. If the rats were treated with cortisone Merck ; , this substance was injected intra.

Min supplementation mix.10 For tube feed ing of prematurely weaned rats this diet was ground in a mortar and suspended in water l g and 2 ml H2O ; and kept at body temperature. Pups were fed doses of 2 ml rat. Three to five rats were housed together. The rats were either fed, during fed or just "handled" every 5 hours sham the first 24 hours after the weaning. In ad dition all rats had access to diet and water ad libitum. Determination of changes in body weight. Pups were weighed daily starting on day 11. In some experiments their weight was determined more often. The number of days each rat needed to regain the wean ing weight weaning weight recovery period"WWRP ; was calculated. This was done by evaluating the body weight gain curve for each individual rat ; . In the thyroxine experiment, the body weight gain between days 11 and 16 and days 16 and 25 was also calculated. Premature weaning. The mother was re moved from the cage on day 15 cortisone experiments ; or 16 thyroxine experi ments ; . Pups were kept in the same cage in which they were reared with the mother before they were weaned clear polycar bonate cage: 47.5 X 20.5 X 26.5 cm ; . The floor was covered with pine chip bedding T1 to the height of 1.5 cm. Draft was mini mized by keeping the lid of the cage cov ered with filter tops.1-' In some experiments an electric heating pad was placed under neath one third of the cage floor, resulting in an increase of the floor temperature in this space to 26.7 to 34.4as opposed to the regular temperature level 20 to 23 ; the remaining two thirds. Normal wean ing occurred when the mother was re moved on day 25. Use of nonlactating female. In some ex periments the lactating female was re placed on the day of premature weaning 16 postnatally ; by a non-lactating female an "aunt" ; . This was a female that had delivered 4 to 5 weeks before and had been weaned from her own litter less than 2 weeks previous to the experiment. Her nipples were ligated after a subcutaneous incision under light ether anesthesia 3 days before she was placed with the prematurely weaned rats. The "aunts" began to clean.
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The incubation of Reichstein's Compound S ; with Cunninyhamella blakesleeana strain H-334 yields 17a-hydroxycorticosterone Kendall's Compound F, hydrocortisone, Reichstein's Compound M ; Hanson, et al., 1953 ; . The presence of cortisone ; in the transformation products was also.
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FORMULARY STATUS Non-Formulary Non-Formulary Generic Generic Non-Formulary Non-Formulary Brand Preferred Generic Non-Formulary Brand Preferred Brand Preferred Brand Preferred Non-Formulary Generic Brand Preferred Generic Generic Non-Formulary Generic Generic Generic Generic Non-Formulary Generic Generic Non-Formulary Brand Preferred Non-Formulary Non-Formulary Generic Non-Formulary Generic Non-Formulary Generic Non-Formulary Generic Brand Preferred Brand Preferred Brand Preferred Brand Preferred Non-Formulary Generic Brand Preferred Generic Non-Formulary Brand Preferred VOPAC ACETAMINOPHEN W CODEINE ACETAMINOPHEN-CODEINE TYLENOL W CODEINE NO.4 ASPIRIN W CODEINE ASPIRIN W CODEINE CARISOPRODOL COMPOUND CODEINE SOMA COMPOUND W CODEINE CODEINE PHOSPHATE CODEINE PHOSPHATE CODEINE SULFATE CODEINE SULFATE CODEINE SULFATE CODEINE SULFATE BUTALBITAL CAFF APAP CODEINE BUTALBITAL-CAFF-APAP-CODEINE FIORICET W CODEINE PHRENILIN W CAFFEINE & CODEINE ASA-BUTALB-CAFF-COD ASCOMP W CODEINE BUTALBITAL COMPOUND W CODEINE FIORINAL W CODEINE #3 PROMETHAZINE W CODEINE COLCHICINE COL-PROBENECID PROBENECID W COLCHICINE WELCHOL COLESTID COLESTIPOL HCL COLESTID COLESTIPOL HCL COLESTID COLESTID COLESTID COLESTIPOL HCL INSTAT INSTAT HELISTAT NEUROCOL SANTYL SUNRISE COMPRESSOR-NEBULIZER LEA'S SHIELD CORTISONE ACETATE CORTISONE ACETATE CRESYLATE BRAND NAME TYLENOL W CODEINE NO.3 GENERIC NAME CODEINE PHOS ACETAMINOPHEN CODEINE PHOS ACETAMINOPHEN CODEINE PHOS ACETAMINOPHEN CODEINE PHOS ACETAMINOPHEN CODEINE PHOS ACETAMINOPHEN CODEINE PHOS ASPIRIN CODEINE PHOS ASPIRIN CODEINE PHOS CARISOPRODOL ASA CODEINE PHOS CARISOPRODOL ASA CODEINE PHOSPHATE CODEINE PHOSPHATE CODEINE SULF CODEINE SULF CODEINE SULF CODEINE SULF CODEINE APAP CAFFEIN BUTALB CODEINE APAP CAFFEIN BUTALB CODEINE APAP CAFFEIN BUTALB CODEINE APAP CAFFEIN BUTALB CODEINE ASA CAFFEINE BUTALB CODEINE ASA CAFFEINE BUTALB CODEINE ASA CAFFEINE BUTALB CODEINE ASA CAFFEINE BUTALB CODEINE PROMETHAZINE HCL COLCHICINE COLCHICINE PROBENECID COLCHICINE PROBENECID COLESEVELAM HCL COLESTIPOL HCL COLESTIPOL HCL COLESTIPOL HCL COLESTIPOL HCL COLESTIPOL HCL COLESTIPOL HCL COLESTIPOL HCL COLESTIPOL HCL COLLAGEN COLLAGEN COLLAGEN COLLAGEN COLLAGENASE COMPRESSOR, FOR NEBULIZER CONTRACEPT BARRIER DEV, VENTED CORTISONE ACETATE CORTISONE ACETATE CRESYL ACE BEN ALC BUTANOL IPA and cosopt Magnesium and phosphorus. Femurs were analyzed for ash, magnesium and in some experiments for fluoride. In the case of rats, blood samples, kidney, heart and femurs were analyzed at the end of the 4-week experimental period. Analytical methods were the same as those described previously 9 ; except for the calcium de termination of the ashed samples where strontium chloride was added at 1% con centration to eliminate phosphate inter ference. The atomic absorption spectrophotometer was equipped with a slotted burner. A low Mg calcinosis of the soft tissues of the dog has been demonstrated 13 ; and appears to involve alterations of the ground substance. Cortisone and estradici have been shown to reduce the synthesis and turnover of mucopolysaccharides and to influence collagen metabolism 14"17 ; . A preliminary study of the affects of these substances upon low Mg calcinosis was made with cortisone acetate and estradici 17B fed at 160 and 8 ppm respectively. The results did not warrant further effort in this respect. RESULTSAND DISCUSSION Experiment 1. Deficiency symptoms of inadequate Mg were observed in animals restricted to the basal diet. Their average cumulative body weight gains were 2.62, 2.77, 2.06 and 2.07 kg for lots 1 to 4, re spectively. No evidence of gross calcinosis was observed when the ration was supple mented with either F", or 200 ppm of Mg. There was calcification in the animals in lots 1 and 4 which was observed in the aortas, heart valves and kidneys but not in.
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The existence of separate receptors for OT and vasopressin in the rat adenohypophysis 6, 7 ; , reinforcing the notion that OT may function as a hypophysiotropic hormone. In addition, CRF-, AVP- and OT-containing neurons in the hypothalamic paraventricular and supraoptic nuclei project to the median eminence and release these peptides into hypophyseal portal blood 810 ; . Here, the concentration of these peptides are several times greater compared to peripheral blood 11-15 ; . Thus, OT as a part of this hypophysiotropic cocktail in the adenohypophyseal circulation could contribute to physiological regulation of ACTH secretion by the hypothalamus. To date, studies examining the effects of OT on ACTH release have not revealed evidence that OT alone, in physiological concentrations 10 nM ; , induces ACTH and creatine.
LDY may include a loss of body fat. Fat and muscle loss are noticed the most in arms, legs and face. The body may also have more fat in the trunk organs and intestines ; and on the back below the neck buffalo hump ; . Women may have increased breast size and more fat in the pelvic area. The authors present a detailed study of the effects of long-term cortisone therapy on 268 patients with asthma and chronic dyspnea. No patient received less than one year of therapy and some received as much as six years. Studies of the bronchial secl'etions, bronchopulmonary ventilation, gas exchange and long range complications were carried out. In 43, 5 per cent of the patients there was a decided respiratory Improvement. The majority of the complications encountered were of three types: 5.7 per and crixivan
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Life." Patients may hold their heads and moan or cry in pain. Sensitivity to light is a common finding. This may make patients reluctant to cooperate with pupil examinations. Level of consciousness varies based on the severity of the hemorrhage. Patients may be alert and coherent, may lose consciousness immediately, or may gradually become less responsive. The decreased level of consciousness is caused by increased intracranial pressure and impairment of cerebral blood flow. Patients may experience generalized seizures. Blood in the subarachnoid space causes meningeal irritation. The patient may exhibit nuchal rigidity. The most commonly affected cranial nerves are III and VI. This is manifested as an enlarged pupil or abnormal gaze. Motor dysfunction may involve one or both limbs on the side opposite the hemorrhage and cubicin. Moderate interactions a-hydrocort , a-methapred , acetocot , acetohexamide , adbeon , adlone-40 , adlone-80 , adrenocot , adrenocot , aldactone , altocor , altoprev , amaryl , anisindione , aquacot , aquamephyton , aquatensen , aquazide h , arava , aristocort , aristocort for injection , aristocort forte , aristopak , aristospan injection , armour thyroid , atorvastatin , azmacort , baycol , bendroflumethiazide , benzthiazide , beta-phos ac , betamethasone , betamethasone acet-betamethasone na phosphate , betamethasone sodium phosphate , bubbli-pred , budesonide , bumetanide , bumex , cardoxin , carozide , celestone , celestone phosphate , celestone soluspan , cell-u-jec , cellcept , cerivastatin , chlorothiazide , chlorpropamide , chlorthalidone , cholestin obsolete ; , clinacort , clinalog , colocort , cort-k , cortastat , cortastat 10 , cortastat la , cortef , cortenema , cortifoam , cortisone , cortone acetate , cotolone , coumadin , cytomel , dalalone , dalalone , dalalone , de-sone la , decadron , decadron 5-12 pak , decadron phosphate, injectable , decadron-la , decaject , decaject , deltasone , demadex , demadex , dep medalone 80 , depacon , depakene , depakote , depakote er , depakote sprinkles , depmedalone , depo-medrol , depo-predate obsolete ; , depoject-80 , depopred , dexacen-4 , dexacort phosphate in respihaler , dexacort-la , dexacorten , dexamethasone , dexamethasone acetate , dexamethasone intensol , dexamethasone sodium phosphate , dexasone , dexasone la , dexone , dexone la , dexpak jr.

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FIG. 4. Time course of cortisone-dependent glucose-6-phosphate metabolism circles ; and glucose-6-phosphate-dependent cortisone reduction squares ; . Values are calculated from the data of Fig. 2 and Fig. 3D and cyanocobalamin. Maximum in the next 12 hours Fig. 6A ; . Corresponding to an increase of staining on actin bands, the acidic isoform of actin at pI 5.6 appeared on 2D- PAGE at 24 hours of development, and increased to 50% of the total actin during the next 12 hours Fig. 6B ; . This increase is due to tyrosine phosphorylation of basic isoforms, because the amount of total actin in spores is relatively constant Fig. 6A, column CBB ; . In aged spores stored at 22C or 4C, the phosphorylation levels of actin tyrosine were well correlated with the spore viability. The high levels of actin phosphorylation were kept for 20 days and declined to undetectable levels in 30 day old spores stored at 22C Fig. 7, filled square symbols ; . It is worthwhile to note that the viability of aged spores at 22C was retained at more than 75% for 20 days, and then decreased in the same manner as the actin tyrosine phosphorylation levels Fig. 7, open square symbols ; . On the other hand, both the phosphorylation and spore viability remained at high levels. Figure 5 a non-linear svm maps the data from the feature space d to the high dimensional feature space f by the non-linear function f and cyclizine. My doctor said rest it for a month and if it still hurts, we'll give you a cortisone injection and cortisone.

Evaporated to dryness in a water bath at 37C under a stream of nitrogen. Each sample was dissolved in 0.055 ml of a methanol-acetone 1: ; solution and applied to Whatman no. 1 chromatography paper which had been washed continuously for 48 hours with redistilled methanol in a modified Soxhlet extraction apparatus Coming Glass Works ; . The paper was removed from the wash and dried immediately before samples were applied. The chromatogram was equilibrated for 2 hours and then was developed by descending chromatography in a benzenehexane-methanol-water 9: 1: 5: ; solvent system for 12 hours. Aldosterone was located using cortisone and cortisol standards. Aldosterone was approximately 8 cm behind cortisone and 15 cm ahead of cortisol in this system after 12 hours of development. The samples were eluted from the paper with redistilled methanol. An aliquot was removed for liquid scintillation counting to allow determination of percent recovery, and then two aliquots equal in volume to the one measured for recovery were evaporated to dryness in a vacuum oven at 35C for radioimmunoassay. A standard curve was constructed for each series of samples analyzed. Standards containing 0, 10, 25, 50, and 1, 000 pg of aldosterone Ciba ; dissolved in ethanol were added to test tubes, 2, 500 counts min of sH-aldosterone was added to each standard, and the solutions were mixed well and evaporated to dryness in a vacuum oven. In addition, standards of 100, 500, and 1, 000 pg of aldosterone were added to pooled plasma samples and carried through the complete purification procedure with each group of samples extracted. Dilute antiserum was prepared immediately before use by diluting stock antiserum with borate buffer 0 . 0 8.0 ; containing 0.1 * gamma globulin human immune serum globulin, Merck, Sharp and Dohme ; and 2% methanol. Threetenths ml of the dilute antiserum was added to the samples and standards, and the solutions were thoroughly mixed without foaming. The tubes were covered with Parafilm, placed in an ice bath, and incubated in a cold room for 2 hours. Cold, saturated ammonium sulfate enzyme grade ; solution 0.3 ml ; was added to each tube. The contents were mixed well, incubated for 15 minutes in an ice bath, and centrifuged at 2, 500 g for 15 minutes at 1C. Three-tenths ml of the supernatant solution was transferred to a scintillation vial. Ten ml of phosphor solution was added to one vial containing 0.3 ml of dilute antiserumsaturated ammonium sulfate 1: background ; , to three vials containing the amount of 8 Haldosterone added as a recovery standard, to and cycloserine.

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This condition is not satisfied in the case of corporations domiciled in the United States if such corporations own less than 10% of the voting stock of PLDT ; or ii ; imposes no income taxes on dividends received by such non-resident non-Philippine corporations from Philippine corporations this condition is not satisfied in the case of corporations domiciled in the United States ; . If neither of the foregoing conditions are met, the dividends paid to the non-resident non-Philippine corporation shall be subject to the regular income tax rate of 32% 35% effective July 1, 2005 ; . Under rulings issued by Philippine tax authorities, Hong Kong is viewed as falling within clause ii ; and, thus, companies that are organized in Hong Kong that are not engaged in trade or business in the Philippines may be entitled to the benefit of the 15% rate. Such rulings, however, were based upon the laws of Hong Kong as in effect at the time such rulings were issued, and any subsequent changes in the relevant laws of Hong Kong may affect the validity of such rulings. As further discussed below, in respect of regular quarterly cash dividends payable on the shares of Series III Convertible Preferred Stock underlying the GDSs, while such shares are on deposit with the Depositary, PLDT intends to make payments of withholding tax pursuant to the terms of such Series III Convertible Preferred Stock, at the rate of 15%, which is the rate applicable to dividends payable to residents of the domicile of the registered shareholder, which is a company organized in Hong Kong not engaged in trade or business in the Philippines. PLDT reserves the right to change the rate at which it makes payments of withholding tax whenever it deems it appropriate under applicable law. Holders will receive regular quarterly cash dividends paid in respect of the Series III Convertible Preferred Stock, but not on the common stock issuable on conversion of such Series III Convertible Preferred Stock, free and clear of withholding tax, such withholding tax being an obligation of PLDT pursuant to the terms of the Series III Convertible Preferred Stock. Any other dividends will be subject to withholding tax at the relevant applicable rate. If the holder of Common Stock is a non-resident foreign partnership, which is treated as a corporation for Philippine tax purposes, dividends on the Common Stock should be subject to a final withholding tax of 32% 35% effective July 1, 2005 ; . Cede & Co., the partnership nominee of Depository Trust Company "DTC" ; , should qualify as a non-resident foreign partnership that would be treated as a corporation for Philippine tax purposes. In certain circumstances where the holder holds Common Stock, a tax treaty rate may be applicable with respect to the Philippine withholding tax. For instance, holders under such circumstances and as to which the Philippines-United States Tax Treaty would be applicable would be eligible for a treaty rate of 25% or 20% in certain instances ; . The 20% treaty rate is generally not applicable in the case of non-resident non-Philippine corporations domiciled in the United States which own less than 10% of the voting stock of PLDT. Holders are required, however, to establish to the Philippine taxing authorities their eligibility for such treaty rate. Philippine tax authorities have prescribed, through an administrative issuance, procedures for availment of tax treaty relief. PLDT intends to pay withholding tax at the reduced treaty rate in respect of shares the registered holder of which is Cede & Co., on the basis that Cede & Co. is a resident of the United States for purposes of the Philippines-United States Tax Treaty. PLDT reserves the right to change the rate at which it makes payments of withholding tax whenever it deems it appropriate under applicable law. Capital Gains Tax and Stock Transaction Tax The Philippine Tax Code provides that gain from the sale of shares of stock in a Philippine corporation shall be treated as derived entirely from sources within the Philippines, regardless of where the shares are sold. Subject to applicable tax treaty rates, the rate of tax on such gain, where the share is not disposed of through the Philippine Stock Exchange, is a final tax of 5% for gains not exceeding Php100, 000 and a final tax of 10% for gains in excess of that amount. The rate is the same for both non-resident individuals and non-resident non-Philippine corporations. While this tax is not collected through withholding, the Philippine Tax Code prohibits a transfer from being recorded on the books of the corporation unless the Philippine Commissioner of Internal Revenue certifies that the tax has been paid or certain other conditions are met. The sale of shares which are listed in and sold through the PSE are subject to the stock transaction tax imposed at the rate of 1 2 the gross selling price. This tax is required to be collected and paid to the government by the selling stockbroker on behalf of his client. Sales of shares other than through a Philippine stock exchange will be subject to Philippine capital gains tax in the manner described above.

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Indicate the annual family gross ; income of this client's household related family members by blood or marriage ; which has been received in the last 12 months prior to evaluation. If several members of the household have income, the income from each source should be added together to arrive at the total. Income from family living outside the client's household would not be counted. No income is coded 00. Income over 98, 000 is coded 98. Unknown income level is coded 99. The number of days the client waited to get into the agency's service programs Mandatory ; . Definition: Indicate the number of days the client waited to get into the agency's treatment service programs. Do not include normal time periods based on the agency's internal policy for "processing" a client prior to admission. A 000 indicates no time waited and 999 indicates unknown. Indicate whether client has given birth within the last 12 months. If the client is male, use code 3 Mandatory ; . 0 No Yes 3 N A Definition: Indicate "1" yes ; if the client has given birth in the last 12 months. Postpartum is the period following childbirth. If the baby is one year old or less, the response to this question would still be "yes". If the baby is older than one year, the response is "2" no ; . If the client is a male, use code 3. Indicate the number of dependents aged 17 and younger claimed by the client on his or her income tax or other government programs Mandatory ; . Definition: Indicate the number of dependents aged 17 and younger claimed by the client on his or her income tax or other government programs such as Medicaid. Dependents are any child ren ; age s ; 17 and under for whom the client is the custodial parent or legal guardian. Enter 0 if there are no dependents ages 17 and under. If more than nine, enter 9. When in doubt, the agency should error on the side of counting the dependent. Identify if the client is developmentally disabled Mandatory ; . 0 No Yes Identify if the client is physically disabled Mandatory and cyclosporine.

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